2019 AUG 14 (NewsRx) -- By a News Reporter-Staff News Editor at Disease Prevention Daily -- A new study on Biotechnology - Molecular Medicine is now available. According to news reporting originating in Catania, Italy, by NewsRx journalists, research stated, “Angiogenesis is involved in many pathological states such as progression of tumours, retinopathy of prematurity and diabetic retinopathy. The latter is a more complex diabetic complication in which neurodegeneration plays a significant role and a leading cause of blindness.”
Financial supporters for this research include Ministero dell’Istruzione, dell’Universita e della Ricerca, Universita di Catania.
The news reporters obtained a quote from the research from the University of Catania, “The vascular endothelial growth factor (VEGF) is a powerful pro-angiogenic factor that acts through three tyrosine kinase receptors (VEGFR-1, VEGFR-2 and VEGFR-3). In this work we studied the anti-angiogenic effect of quercetin (Q) and some of its derivates in human microvascular endothelial cells, as a blood retinal barrier model, after stimulation with VEGF-A. We found that a permethylated form of Q, namely 8MQPM, more than the simple Q, is a potent inhibitor of angiogenesis both in vitro and ex vivo. Our results showed that these compounds inhibited cell viability and migration and disrupted the formation of microvessels in rabbit aortic ring. The addition of Q and more significantly 8MQPM caused recoveries or completely re-establish the transendothelial electrical resistance (TEER) to the control values and suppressed the activation of VEGFR2 downstream signalling molecules such as AKT, extracellular signal-regulated kinase, and c-Jun N-terminal kinase.”
According to the news reporters, the research concluded: “Taken together, these data suggest that 8MQPM might have an important role in the contrast of angiogenesis-related diseases.”
For more information on this research see: Anti-angiogenic effect of quercetin and its 8-methyl pentamethyl ether derivative in human microvascular endothelial cells. Journal of Cellular and Molecular Medicine, 2019;():. Journal of Cellular and Molecular Medicine can be contacted at: Blackwell Publishing Inc, 350 Main St, Malden, MA 02148, USA. (Wiley-Blackwell - http://www.wiley.com/; Journal of Cellular and Molecular Medicine - http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1582-4934)
Our news correspondents report that additional information may be obtained by contacting G. Lupo, Section of Medical Biochemistry, Dept. of Biomedical and Biotechnological Sciences (Biometec), School of Medicine, University of Catania, Catania, Italy. Additional authors for this research include M.T. Cambria, M. Olivieri, C. Rocco, N. Caporarello, A. Longo, G. Zanghi, M. Salmeri, M.C. Foti and C.D Anfuso.
The direct object identifier (DOI) for that additional information is: https://doi.org/10.1111/jcmm.14455. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.
The publisher of the Journal of Cellular and Molecular Medicine can be contacted at: Blackwell Publishing Inc, 350 Main St, Malden, MA 02148, USA.
(Our reports deliver fact-based news of research and discoveries from around the world.)
Copyright © 2019 NewsRx LLC, Disease Prevention Daily, source Health Newsletters