"The pattern in the last few days are not really very promising but, as I always repeat, we will always remain optimistic and will always remain pushing," Sheikh Mohammed said at the Munich Security Conference.
Sheikh Mohammed, who is also foreign minister, said he could not get into the details of negotiations but as with past deals there were two elements, the humanitarian conditions in Gaza and the number of Palestinians who would be released in exchange for hostages held by Hamas.
"I believe in this agreement we are talking at a bigger scale and we still see some difficulties on the humanitarian part of these negotiations," he said.
He added that he thought that if negotiations on the humanitarian element of any deal progressed then the obstacle over the numbers of those released would be ultimately tackled.
Talks involving officials from Qatar, Egypt, Israel and the United States have so far not yielded a deal for a pause in the fighting.
(Reporting by Maha El Dahan and Hatem Maher; Editing by Frances Kerry)
