The PhenoCycler-Fusion platform facilitates the understanding of the cellular compositions, neighborhoods, and functional states that are present in complex diseases, and that next generation therapeutics may be able to target. Bringing a new level of clarity to this complex biology will help explain why individual patients have varying degrees of success in terms of their response to treatment.
“Akoya’s industry-leading spatial biology platform is enabling our experts to rapidly map the presence, location, phenotype, and interaction of millions of cells,” said Professor
With multi-slide automation, the PhenoCycler-Fusion system enables researchers to generate ultrahigh-plex spatial phenotyping data for larger and more complex samples at unprecedented speed and scale. Studies conducted using the platform reinforce the value of single-cell ultrahigh-plex spatial phenotyping as a powerful tool for defining spatial tissue signatures associated with therapy response and resistance.i
"We are extremely excited to be an integral part of this important initiative," said
The hospital-based QSBC initiative is led by the
“Spatial biology is revolutionizing the pathology field by enabling deeper biology and clinical markers to be measured from a single tissue section,” said Dr. Arutha Kulasinghe, QSBC Scientific Director and co-lead. “Digitizing tissues is likely to lead to new fields in spatial informatics and data analysis where machine learning and predictive biomarkers can be rapidly developed and deployed to personalize therapies.”
A video about the QSBC can be viewed here: https://www.youtube.com/watch?v=6ZcHWpqYJoM
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i Jhaveri N, et al. Mapping the Spatial Proteome of Head and Neck Tumors: Key Immune Mediators and Metabolic Determinants in the Tumor Microenvironment. GEN Biotechnology 2023 2:5, 418-434
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