ALLIGATOR BIOSCIENCE AB - 1st Presentation supports dosing regimen for mitazalimab in combination with FOLFORINOX and improvement of antitumor response
- 2nd Presentation highlights potential of ATOR-4066 to induce tumor localized immune cell activation and strongly support further development of the candidate in clinical trials
The first presentation, entitled “Mitazalimab, a potent CD40 agonist in combination with FOLFIRINOX demonstrates changes consistent with increased immune activation in TME and peripheral blood in a preclinical pancreatic cancer tumor model”, provides further support to the unique dosing regimen chosen for the OPTIMIZE-1 Phase 2 study in first line metastatic pancreatic cancer, resulting in an increased tumoricidal immune profile, including a marked increase in effector CD8+ T cells in the tumor microenvironment. Taken together, these preclinical data provides a mechanistic explanation to the unprecedented DoR and OS observed in OPTIMIZE-1 and corroborates the previously reported associations between clinical response and T cell activation, highlighting the mitazalimab-specific contribution to tumor responses. Moreover, the presentation underlines the synergistic potential of this combination for an improved antitumor response compared to FOLFIRINOX alone.
The second presentation, entitled “ATOR-4066, a Neo-X-Prime™ bispecific antibody targeting CD40 and CEACAM5, induces tumor localized immune cell activation in preclinical in vivo tumor model”, demonstrates that ATOR-4066 activates tumor infiltrating dendritic cells and macrophages resulting in increases in activated tumor infiltrating T cells, thus creating a pro-inflammatory tumor microenvironment leading to single-agent complete responses in translational tumor models. These data strongly support further development and clinical testing of ATOR-4066.
"We are very pleased to be presenting data for two of our promising CD40-candidates at this year's prestigious AACR Annual Meeting, which highlight the increasing strength and progress of our CD40 program," said Søren Bregenholt, CEO of Alligator Bioscience. "The first presentation details further supporting evidence of the potential of our lead asset mitazalimab to provide significant clinical benefit to pancreatic cancer patients in combination with chemotherapy when compared to standard of care, as demonstrated in the outstanding top-line results from our OPTIMIZE-1 study. The second presentation suggests CD40 could be activated in a very selective manner, which would open the way to an even more targeted therapeutic approach. These data strongly support the further development of ATOR-4066 in clincial trials, which Alligator is currently working toward."
Poster Presentation Details
Abstract Number: 2376
Title: Mitazalimab, a potent CD40 agonist in combination with FOLFIRINOX demonstrates changes consistent with increased immune activation in TME and peripheral blood in a preclinical pancreatic cancer tumor model
Date/Time:
Session: PO.CL06.07 - Antibodies 1
Presenter:
Location: Poster Section 38, Poster Board 22
Abstract Number: 5309
Title: ATOR-4066, a Neo-X-Prime™ bispecific antibody targeting CD40 and CEACAM5, induces tumor localized immune cell activation in preclinical in vivo tumor model
Date/Time:
Session: PO.IM01.17 - Immune Modulation Employing Agonist or Co-Stimulatory Approaches
Presenter:
Location: Poster Section 3, Poster Board 18
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