Certain Options of Alpine Immune Sciences, Inc. are subject to a Lock-Up Agreement Ending on 22-DEC-2023. These Options will be under lockup for 46 days starting from 6-NOV-2023 to 22-DEC-2023.

Details:
The directors and officers and certain stockholders have agreed that, without the prior written consent of the representatives on behalf of the underwriters, they will not publicly disclose an intention to, during the period ending 60 days after the date of this prospectus supplement or during the period ending 45 days after the date of this prospectus supplement (in the case of directors, officers and certain stockholders), or, each, a restricted period.