On November 12, 2021, Anika Therapeutics, Inc. entered into a Third Amendment to Credit Agreement amending its existing revolving line of credit agreement dated October 24, 2017 with Bank of America, N.A., which revolving line of credit agreement, as amended to date (including by such Third Amendment). Under the amended agreement, Bank of America, N.A. serves as administrative agent, issuer of letters of credit and swingline lender for a $75.0 million senior revolving line of credit with a maturity date of November 12, 2026. Subject to certain conditions, its may request up to an additional $75.0 million in commitments for a maximum aggregate commitment of $150.0 million, subject to the approval of the Revolving Lenders referred to in the Amended Agreement. Loans under the Amended Agreement generally will bear interest at a rate equal to (a) the Bloomberg Short-Term Bank Yield Index, or BSBY, rate plus (b) an additional percentage that will range from 0.25% to 1.00%, based on its consolidated leverage ratio at the time of the borrowings.