Corporate Presentation
NASDAQ: ABUS
www.arbutusbio.com
June 6, 2022
Forward-LookingStatements
This presentation contains forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995 and Canadian securities laws. All statements that are not historical facts are hereby identified as forward-lookingstatements for this purpose and include, among others, statements relating to: the potential market opportunity for HBV; Arbutus' ability to meet a significant unmet medical need; the sufficiency of Arbutus' cash and cash equivalents for the anticipated durations; the expected cost, timing and results of Arbutus' clinical development plans and clinical trials, including its clinical collaborations with third parties; the potential for Arbutus' product candidates to achieve their desired or anticipated outcomes; Arbutus' expectations regarding the timing and clinical development of Arbutus' product candidates, including its articulated clinical objectives; the timeline to a combination cure for HBV; Arbutus' coronavirus strategy; Arbutus' expectations regarding its technology licensed to third parties; the expected timing and payments associated with strategic and/or licensing agreements; the patent infringement lawsuit against Moderna; and other statements relating to Arbutus' future operations, future financial performance, future financial condition, prospects or other future events.
With respect to the forward-looking statements contained in this presentation, Arbutus has made numerous assumptions regarding, among other things: the timely receipt of expected payments; the effectiveness and timeliness of pre-clinical studies and clinical trials, and the usefulness of the data; the timeliness of regulatory approvals; the continued demand for Arbutus' assets; and the stability of economic and market conditions. While Arbutus considers these assumptions to be reasonable, these assumptions are inherently subject to significant business, economic, competitive, market and social uncertainties, and contingencies including uncertainties and contingencies related to the ongoing COVID-19 pandemic and patent litigation matters. Forward-looking statements herein involve known and unknown risks, uncertainties and other factors that may cause the actual results, events or developments to be materially different from any future results, events or developments expressed or implied by such forward-looking statements. Such factors include, among others: anticipated pre-clinical and clinical trials may be more costly or take longer to complete than anticipated, and may never be initiated or completed, or may not generate results that warrant future development of the tested drug candidate; changes in Arbutus' strategy regarding its product candidates and clinical development activities; Arbutus may not receive the necessary regulatory approvals for the clinical development of Arbutus' products; economic and market conditions may worsen; uncertainties associated with litigation generally and patent litigation specifically; market shifts may require a change in strategic focus; the parties may never realize the expected benefits of the collaborations; and the ongoing COVID-19 pandemic could significantly disrupt Arbutus' clinical development programs. A more complete discussion of the risks and uncertainties facing Arbutus appears in Arbutus' Annual Report on Form 10-K, Quarterly Report on Form 10-Q and Arbutus' periodic disclosure filings, which are available at www.sec.gov and at www.sedar.com. All forward-looking statements herein are qualified in their entirety by this cautionary statement, and Arbutus disclaims any obligation to revise or update any such forward-looking statements or to publicly announce the result of any revisions to any of the forward-looking statements contained herein to reflect future results, events or developments, except as required by law.
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Our Strategy
Leverage the proven track record of success established with our team's expertise in understanding and treating viral infections by discovering and developing a broad, differentiated pipeline of therapies targeting chronic HBV, COVID-19, and future coronavirus outbreaks.
Develop a combination therapy that includes antivirals and immunologics to provide a finite duration treatment for people with cHBV that results in >20% functional cure rate.
Develop novel oral pan coronavirus antivirals targeting essential viral proteins with the goal of reducing
hospitalizations and providing pre- exposure prophylactic therapy.
HBV: Hepatitis B Virus | cHBV: chronic HBV | 3 |
Investment Highlights
Indications with | Team | Broad portfolio | Lead HBV | Strong | Patented | ||||||||||||||
significant unmet | with virology | of internally | compound - AB-729 | financial position | LNP | ||||||||||||||
medical need & | expertise and | discovered assets | RNAi therapeutic in | technology | |||||||||||||||
large market | proven track | with distinct MOAs | multiple Phase 2a | ||||||||||||||||
opportunities | record | combination | |||||||||||||||||
clinical trials | |||||||||||||||||||
Focused on | Discovered, | RNAi therapeutic | Data shows AB-729 is | Cash runway | Receiving licensing |
developing functional cure | developed & | Capsid Inhibitor | generally safe | into Q2 2024 | royalties arising from |
for HBV and oral pan- | commercialized | PD-L1 inhibitor | and well tolerated and | Alnylam's Onpattro® | |
coronavirus therapeutics | multiple drugs | RNA destabilizer | has shown meaningful | and seeking damages for | |
Mpro inhibitor | suppression | Moderna-COVID-19 | |||
Nsp12 polymerase inhibitor | of HBsAg expression | vaccine sales |
MOA: Mechanism of Action | PD-L1: Programmed death-ligand1 | Mpro: Main protease | NSP12: Non-structural protein | HBsAg: Hepatitis B surface antigen | 4 |
Broad Pipeline
HBV
COVID-19
RNAi Therapeutic | AB-729 |
Capsid Inhibitor (oral) | AB-836 |
PD-L1 Inhibitor (oral) | AB-101 |
RNA destabilizer (oral) | AB-161 |
Mpro inhibitor (oral)
Nsp12 polymerase inhibitor (oral)
Lead Optimization IND Enabling | Phase 1 | Phase 2 | Phase 3 | Marketed |
AB-729-001single-ascending dose / multiple-ascending dose
AB-729-201 Combo trial (AB-729 + Peg-IFNa-2a + NA)
Combo trial (AB-729 + core inhibitor + NA)
AB-729-202 Combo trial (AB-729 + vaccine + NA )
AB-836-001single-ascending dose / multiple-ascending dose
NA: Nucleoside Analogue | 5 |
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Disclaimer
Arbutus Biopharma Corp. published this content on 06 June 2022 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 06 June 2022 11:51:09 UTC.