AtheroNova Inc. announced a major milestone with the completion of the active treatment portion of its Phase 1 clinical trial with its lead compound, AHRO-001. The Phase 1 study objective is to evaluate the safety, tolerability and pharmacokinetics of AHRO-001 in healthy volunteers. The clinical study is being conducted in Russia with AtheroNova's licensing partner, OOO CardioNova.

The Phase 1 study, with a planned enrollment of 54 subjects, was designed to characterize the safety of AHRO-001 across three dose ranges and possible pharmacokinetics. It is a multi-center, randomized, double-blind, placebo-controlled, single and multiple dose escalation, first-in-human study of AHRO-001 administered via oral tablet to healthy adult volunteers at sites in Moscow and St. Petersburg, Russia.

All subjects have been dosed and received either placebo or AHRO-001 in doses ranging from 18.75 mg/kg to 37.5 mg/kg per day. Top line data is expected to be announced in the first quarter of 2014.