Banco Santander S A : communicates that it has carried out the following transactions over its own shares between 6 October and 14 October relating to the buyback programme

Banco Santander, S.A., in compliance with the Securities Market legislation, hereby communicates the following:

OTHER RELEVANT INFORMATION

Reference is made to our notice of inside information of 6 October, 2021 (official registry number 1086), relating to the buyback programme of own shares (the "Buy-backProgramme") approved by the Board of Directors of Banco Santander, S.A. Pursuant to article 5 of Regulation (EU) no. 596/2014 on Market Abuse of 16 April 2014, and articles 2.2 and 2.3 of Commission Delegated Regulation (EU) 2016/1052, of 8 March 2016, Banco Santander, S.A. informs -on the basis of the information received from Morgan Stanley Europe SE as intermediary in charge of executing the Buy-back Programme- that it has carried out the following transactions over its own shares between 6 October and 14 October, 2021 (both included):

Date	Security		Transaction	Trading venue	Number of	Weighted
					shares	average price
						(€)
06/10/2021	SAN.MC		Purchase	XMAD	5,799,954	€3.2229
07/10/2021	SAN.MC		Purchase	XMAD	5,772,396	€3.3114
08/10/2021	SAN.MC		Purchase	XMAD	5,229,125	€3.3562
11/10/2021	SAN.MC		Purchase	XMAD	5,507,157	€3.3555
12/10/2021	SAN.MC		Purchase	XMAD	5,909,094	€3.3490
13/10/2021	SAN.MC		Purchase	XMAD	6,090,491	€3.3213
14/10/2021	SAN.MC		Purchase	XMAD	6,983,255	€3.3157
		TOTAL		41,291,472

Issuer name: Banco Santander, S.A. - LEI 5493006QMFDDMYWIAM13

Reference of the financial instrument: ordinary shares - Code ISIN ES0113900J37

Detailed information of the transactions carried out within the referred period is attached as Annex I. Boadilla del Monte (Madrid), 15 October 2021

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ANNEX I

Detailed information on each of the transactions carried out within the context of the Buy-back Programme between 6 October and 14 October 2021 (both included)

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