Banco Santander S A : communicates the transactions over its own shares which it has carried out between 19th and 27th April under the buyback programme

Banco Santander, S.A. (the "Bank" or "Banco Santander"), in compliance with the Securities Market legislation, hereby communicates the following:

OTHER RELEVANT INFORMATION

Reference is made to our notice of inside information of March 14, 2022 (official registry number 1360), relating to the buyback programme of own shares (the "Buy-back Programme") approved by the Board of Directors of Banco Santander.

Pursuant to article 5 of Regulation (EU) no. 596/2014 on Market Abuse of 16 April 2014, and articles 2.2 and 2.3 of Commission Delegated Regulation (EU) 2016/1052, of 8 March 2016, the Bank informs that it has carried out the following transactions over its own shares between 19/04/2022 and 27/04/2022 (both inclusive):

Date	Security	Transaction	Trading Venue	Number of shares	Weighted Average Price (€)
19/04/2022	SAN.MC	Purchase	XMAD	6,500,000	3.1553
20/04/2022	SAN.MC	Purchase	XMAD	6,700,000	3.2227
21/04/2022	SAN.MC	Purchase	XMAD	6,000,000	3.2142
22/04/2022	SAN.MC	Purchase	XMAD	7,000,000	3.1888
25/04/2022	SAN.MC	Purchase	XMAD	10,500,000	3.1050
26/04/2022	SAN.MC	Purchase	XMAD	11,150,000	3.0077
27/04/2022	SAN.MC	Purchase	XMAD	12,000,000	2.8247
TOTAL	59,850,000

Issuer name: Banco Santander, S.A. - LEI 5493006QMFDDMYWIAM13

Reference of the financial instrument: ordinary shares - Code ISIN ES0113900J37

Detailed information of the transactions carried out within the referred period is attached as Annex I.

Boadilla del Monte (Madrid), 28 April 2022

ANNEX I

Detailed information on each of the transactions carried out within the context of the Buy-back Programmebetween 19/04/2022 and 27/04/2022 (both inclusive)