Baudax Bio, Inc. announced that the first cohort has been dosed in a First-in-Man, Phase 1 clinical study evaluating the safety, tolerability and pharmacokinetics of BX2000, a rapid onset, ultra-short acting neuromuscular blocking (NMB) agent, in healthy volunteers. This double-blind, placebo-controlled study will investigate single ascending doses of BX2000 administered as an intravenous bolus injection compared to placebo. The study is comprised of up to 10 dosing cohorts and each cohort will enroll 8 patients.

The study will evaluate the effect of BX2000 on safety, including heart rate, blood pressure, corrected QT interval, pharmacokinetics, and the time course of the neuromuscular blocking profile. Subjects will be monitored at an inpatient facility for 24 hours following administration of BX2000. There will also be follow-up visits conducted on Day 8 and follow-up will take place approximately 2 and 4 weeks after dosing to determine the continued safety of study participants.