BerGenBio ASA announced that a poster highlighting final results from a Phase 2 clinical study of its highly selective AXL inhibitor bemcentinib in patients with Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS) was presented during the 2023 American Society of Hematology (ASH) Annual Meeting being on December 9th in San Diego, CA. The data presented by Professor Sonja Loges, MD, Ph.D. of the University Medical Centre Mannheim, Heidelberg, Germany, showed that bemcentinib was well tolerated in AML and MDS patients. Durable responses were observed across all cohorts with bemcentinib as monotherapy and in combination with chemotherapy.

In addition, longitudinal samples analyzed from patients enrolled in the study showed that bemcentinIB inhibited pAXL and downstream markers of activation. This large Phase 2 study included 122 patients in several cohorts of AML and MDS patients treated with bemcentinib monotherapy or in combination with two different chemotherapies.