PRESS RELEASE : Biotest AG: Biotest supports clinical study with Pentaglobin(R) in COVID-19 at the University Hospital AKH Vienna

DGAP-News: Biotest AG / Key word(s): Study 
Biotest AG: Biotest supports clinical study with Pentaglobin(R) in COVID-19 at the University Hospital AKH Vienna 
2021-02-23 / 07:00 
The issuer is solely responsible for the content of this announcement. 
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PRESS RELEASE 
Biotest supports clinical study with Pentaglobin^(R) in COVID-19 at the University Hospital AKH Vienna 
  . University Hospital AKH Vienna investigates various COVID-19 therapies in platform trial (ACOVACT) 
  . Additional study arm with Pentaglobin^(R) started 
  . Pentaglobin^(R) supports the immune system in eliminating bacteria and toxins and can regulate excessive immune 
    responses 
 
Dreieich, 23 February 2021. In a study arm of the ACOVACT trial, the treatment of patients with severe COVID-19 with 
Pentaglobin^(R) has been started. ACOVACT (Austrian CoronaVirus Adaptive Clinical Trial) is a multicentre, randomised, 
controlled, open-label platform trial initiated by the University Hospital AKH Vienna to study various antiviral and 
adjunctive therapies for COVID-19 patients. 
In the study arm, investigating immunomodulatory therapies, 20 COVID-19 patients in intensive care with pneumonia and 
elevated inflammatory markers and with a risk of developing sepsis or acute respiratory failure will be treated with 
Pentaglobin^(R). 
"Due to its immunomodulating effect, we believe Pentaglobin^(R) offers a promising approach for treating severe courses 
of COVID-19 disease and we aim to investigate this more in detail in the ACOVACT trial," emphasises Univ.-Prof. Dr. 
Roman Ullrich, Senior Consultant Intensive Care Medicine at the University Clinic for Anaesthesia at the Medical 
University Vienna who is the principal investigator of the sub-study with Pentaglobin^(R). 
The IgM-enriched immunoglobulin preparation Pentaglobin^(R) is an established treatment option for patients with severe 
bacterial infections. A meta-analysis of patients with sepsis and septic shock demonstrated a significant reduction in 
mortality and a shorter duration of mechanical ventilation.^[1] Pentaglobin^(R) has an immunomodulatory effect and 
could therefore help to positively influence the often excessive immune response in severe courses of COVID-19. In 
addition, the antibodies in Pentaglobin^(R) can bind to a variety of bacteria and their toxins, supporting their 
destruction by the immune system. Secondary bacterial infections are increasingly being observed in COVID-19 patients 
with severe courses of the disease. Biotest supports the project within the scope of an academic-industry collaboration 
(Investigator Initiated Study). 
About Pentaglobin^(R) 
Pentaglobin^(R) is the first and only IgM-enriched immunoglobulin preparation for intravenous use. Pentaglobin^(R) 
significantly increases the survival rate of patients with severe bacterial infections and acts against a broad 
spectrum of bacterial pathogens. Pentaglobin^(R) acts anti-bacterial by neutralization of bacterial endo- and exotoxins 
and anti-inflammatory by scavenging excessively activated complement factors. Pentaglobin^(R) is licensed in several 
countries for the treatment of severe bacterial infections in combination with antibiotics. 
About COVID-19 
COVID-19 is a respiratory disease caused by the novel severe acute respiratory syndrome corona virus 2 variant 
(SARS-CoV-2). While most cases are mild or asymptomatic, COVID-19 patients may present at the hospital with typical 
signs of pneumonia requiring oxygen support. This disease stage is regularly accompanied by an excessive immune 
response and can lead to systemic inflammation reactions. Furthermore, patients may progress to critical disease with 
need for intensive care, including invasive mechanical ventilation. This clinical picture and course of the disease 
resembles that of severe community acquired pneumonia (sCAP) caused by other pathogens. 
About Biotest 
Biotest is a provider of plasma proteins and biological drugs. With a value added chain that extends from pre-clinical 
and clinical development to worldwide sales, Biotest has specialised primarily in the areas of clinical immunology, 
haematology and intensive care medicine. Biotest develops and markets immunoglobulins, coagulation factors and albumin 
based on human blood plasma. These are used for diseases of the immune and haematopoietic systems. Biotest has more 
than 1,900 employees worldwide. The ordinary and preference shares of Biotest AG are listed in the Prime Standard on 
the German stock exchange. 
IR contact 
Dr Monika Buttkereit 
Phone: [phone] 
Mail: [e-mail] 
PR contact 
Dirk Neumüller 
Phone: [phone] 
Mail: [e-mail] 
Biotest AG, Landsteinerstr. 5, 63303 Dreieich, Germany, www.biotest.com 
Ordinary shares: securities' ID No. 522720; ISIN DE0005227201 
Preference shares: securities' ID No. 522723; ISIN DE0005227235 
Listing: Frankfurt (Prime Standard) 
Open Market: Berlin, Düsseldorf, Hamburg/ Hanover, Munich, Stuttgart, Tradegate 
Disclaimer 
This document contains forward-looking statements on overall economic development as well as on the business, earnings, 
financial and assets position of Biotest AG and its subsidiaries. These statements are based on current plans, 
estimates, forecasts and expectations of the company and are thus subject to risks and elements of uncertainty that 
could result in significant deviation of actual developments from expected developments. The forward-looking statements 
are only valid at the time of publication. Biotest does not intend to update the forward-looking statements and assumes 
no obligation to do so. 
^[1] Cui et al. Ann. Intensive Care 9, 27 (2019). https://doi.org/10.1186/s13613-019-0501-3 
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2021-02-23 Dissemination of a Corporate News, transmitted by DGAP - a service of EQS Group AG. 
The issuer is solely responsible for the content of this announcement. 
The DGAP Distribution Services include Regulatory Announcements, Financial/Corporate News and Press Releases. 
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Language:     English 
Company:      Biotest AG 
              Landsteinerstraße 5 
              63303 Dreieich 
              Germany 
Phone:        0 61 03 - 8 01-0 
Fax:          0 61 03 - 8 01-150 
E-mail:       [e-mail] 
Internet:     http://www.biotest.de 
ISIN:         DE0005227235, DE0005227201 
WKN:          522723, 522720 
Listed:       Regulated Market in Frankfurt (Prime Standard); Regulated Unofficial Market in Berlin, Dusseldorf, 
              Hamburg, Hanover, Munich, Stuttgart, Tradegate Exchange 
EQS News ID:  1170123 
 
End of News   DGAP News Service 
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1170123 2021-02-23

(END) Dow Jones Newswires

February 23, 2021 01:02 ET (06:02 GMT)