BioVaxys Technology Corp. announced that interim results from its ongoing preclinical of BVX-1021, the Company's vaccine for SARS-CoV-1 which is being evaluated in a collaboration with The Ohio State University to develop a pan-sarbecovirus vaccine, show an excellent emerging tolerability profile with no observed side effects or noteworthy clinical observations. BVX-1021 is the subject of an ongoing research collaboration between Ohio State and BioVaxys that is evaluating the Company's novel approach for a "universal vaccine" that can treat a broad range of sarbecoviruses.

Sarbecoviruses are a family of viruses that include all Covid-19 variants, the SARS-CoV-1 virus responsible for the 2003 global SARS pandemic, and a broad range of other potentially dangerous zoonotic viruses. The collaboration is evaluating the combination of BioVaxys' BVX-0320 and BVX-1021 in a guinea pig model; BVX-1021 is a hapten-modified recombinant S1 subunit of the spike protein from the SARS1 virus, whereas BVX-0320, is a hapten-modified recombinant S1 subunit of the spike protein from SARS-CoV-2, the virus which causes Covid-19. Three weeks post-administration of BVX-1021 in the guinea pig animal model, no toxicities or body weight changes have been observed, nor any injection site reactions.

The next step of the study is the follow-on immunization of the test animals with BVX-0320, the Company's Covid-19 vaccine candidate, currently underway at Ohio State. The major endpoints of the study are the development of virus-neutralizing antibodies to live virus SARS2 and other sarbecoviruses, including bat and pangolin SARS-related coronaviruses. The presence of neutralizing antibodies in the animal model would strongly suggest that BVX-1021 would confer an additional immune response across all sarbecoviruses in those people fully vaccinated for Covid-19, as well as those with natural immunity.