New clinical research for the DiviTum TKa test will be presented at the 2023 San Antonio Breast Cancer Symposium (SABCS)
“This is the eighth consecutive year that data for our DiviTum TKa test has been accepted by SABCS, the world’s largest and most important breast cancer conference. All three abstracts are very interesting but seeing DiviTum TKa performing as well or better than other standard monitoring tools in several patient case studies from the TK IMPACT trial of course makes me extra happy and proud,” said
More about the three abstracts
The abstract “Serum thymidine kinase activity as a “real-time” biomarker of tumor response to CDK4/6 inhibition in HR+ metastatic breast cancer” is based on the ongoing TK IMPACT study at
“Genomic and PAM50 correlates of serum thymidine kinase activity (sTKa) in patients (pts) with metastatic breast cancer (MBC) treated with palbociclib (P) and Fulvestrant (F) in the PYTHIA trial” is a sub-analysis from the PYTHIA study for which top-line results have already been presented. The study looked at the correlation between TKa levels, intrinsic breast cancer subtypes, and the presence of the three most common genomic tumor mutations (p53, PIK3CA, and ESR1). The data showed that baseline TKa levels were higher in luminal B and HER2-enriched intrinsic subtypes and that the DiviTum TKa test was more strongly predictive of progression-free survival than the presence of mutations in p53, PIK3CA, or ESR1 genes.
“Use of DiviTum-TKa test as a biomarker assay for CDK4/6 inhibitor medication compliance and drug-drug interaction assessment in ER/PR positive metastatic breast cancer” is based on the ongoing prospective clinical trial that was started at Yale in
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