BlackRock Science and Technology Trust : Shareholder Report - Semi-Annual - Closed-End Equity

JUNE 30, 2022

2022 Semi-Annual Report (Unaudited)

BlackRock Energy and Resources Trust (BGR)

BlackRock Enhanced Capital and Income Fund, Inc. (CII)

BlackRock Enhanced Equity Dividend Trust (BDJ)

BlackRock Enhanced Global Dividend Trust (BOE)

BlackRock Enhanced International Dividend Trust (BGY)

BlackRock Health Sciences Trust (BME)

BlackRock Health Sciences Trust II (BMEZ)

BlackRock Innovation and Growth Trust (BIGZ)

BlackRock Resources & Commodities Strategy Trust (BCX)

BlackRock Science and Technology Trust (BST)

BlackRock Science and Technology Trust II (BSTZ)

BlackRock Utilities, Infrastructure & Power Opportunities Trust (BUI)

Not FDIC Insured • May Lose Value • No Bank Guarantee

NM0822U-2398030-1/176

Supplemental Information (unaudited)

Section 19(a) Notices

BlackRock Energy and Resources Trust's (BGR), BlackRock Enhanced Capital and Income Fund, Inc.'s (CII), BlackRock Enhanced Equity Dividend Trust's (BDJ), BlackRock Enhanced Global Dividend Trust's (BOE), BlackRock Enhanced International Dividend Trust's (BGY), BlackRock Health Sciences Trust's (BME), BlackRock Health Sciences Trust II's (BMEZ), BlackRock Innovation and Growth Trust's (BIGZ), BlackRock Resources & Commodities Strategy Trust's (BCX), BlackRock Science and Technology Trust's (BST), BlackRock Science and Technology Trust II's (BSTZ) and BlackRock Utilities, Infrastructure & Power Opportunities Trust's (BUI) (collectively, the"Trusts" or individually, a "Trust") amounts and sources of distributions reported are estimates and are being provided to you pursuant to regulatory requirements and are not being provided for tax reporting purposes. The actual amounts and sources for tax reporting purposes will depend upon each Trust's investment experience during the remainder of its fiscal year and may be subject to changes based on tax regulations. Each Trust will provide a Form 1099-DIV each calendar year that will tell you how to report these distributions for U.S. federal income tax purposes.

June 30, 2022

			Total Cumulative Distributions				% Breakdown of the Total Cumulative
			for the Fiscal Period					Distributions for the Fiscal Period
		Net Realized	Net Realized		Total Per		Net Realized	Net Realized		Total Per
	Net	Capital Gains	Capital Gains	Return of	Common	Net	Capital Gains	Capital Gains	Return of	Common
Trust Name	Income		Short-Term		Long-Term	Capital (a)	Share	Income	Short-Term	Long-Term	Capital	Share
BGR . . . . . . . . . . . . . . . . . . . . . . . . . . . . .	$ 0.186381	$	-	$	-	$ 0.069619	$ 0.256000		73%	-%	-%	27%	100%
CII . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .	0.025717		0.343132		0.228151	-	0.597000		4	57	39	-	100
BDJ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .	0.082480		0.093121		0.149199	-	0.324800		25	29	46	-	100
BOE . . . . . . . . . . . . . . . . . . . . . . . . . . . . .	0.126586		-		0.251414	-	0.378000		33	-	67	-	100
BGY . . . . . . . . . . . . . . . . . . . . . . . . . . . . .	0.071189		-		0.050024	0.081587	0.202800		35	-	25	40	100
BME . . . . . . . . . . . . . . . . . . . . . . . . . . . . .	0.035721		-		1.242279	-	1.278000		3	-	97	-	100
BMEZ . . . . . . . . . . . . . . . . . . . . . . . . . . . .	-		0.357947		0.512053	-	0.870000		-	41	59	-	100
BIGZ . . . . . . . . . . . . . . . . . . . . . . . . . . . . .	-		-		-	0.570000	0.570000		-	-	-	100	100
BCX . . . . . . . . . . . . . . . . . . . . . . . . . . . . .	0.154480		-		-	0.105520	0.260000		59	-	-	41	100
BST. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .	-		-		1.500000	-	1.500000		-	-	100	-	100
BSTZ . . . . . . . . . . . . . . . . . . . . . . . . . . . .	-		0.380441		0.771559	-	1.152000		-	33	67	-	100
BUI . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .	0.210835		-		0.482989	0.032176	0.726000		29	-	67	4	100

1. Each Trust estimates that it has distributed more than its net income and net realized capital gains; therefore, a portion of the distribution may be a return of capital. A return of capital may occur, for example, when some or all of the shareholder's investment in a Trust is returned to the shareholder. A return of capital does not necessarily reflect a Trust's investment performance and should not be confused with "yield" or "income." When distributions exceed total return performance, the difference will reduce a Trust's net asset value per share.

Section 19(a) notices for the Trusts, as applicable, are available on the BlackRock website at blackrock.com.

Section 19(b) Disclosure

The Trusts, acting pursuant to a U.S. Securities and Exchange Commission ("SEC") exemptive order and with the approval of each Trust's Board of Trustees (the "Board"), each have adopted a managed distribution plan, consistent with its investment objectives and policies to support a level distribution of income, capital gains and/or return of capital (the "Plan"). In accordance with the Plans, the Trusts currently distribute the following fixed amounts per share on a monthly basis:

		Amount Per
Exchange Symbol	Common Share
BGR . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .	$	0.0490
CII . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .		0.0995
BDJ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .		0.0562
BOE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .		0.0630
BGY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .		0.0338
BME . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .		0.2130
BMEZ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .		0.1450
BIGZ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .		0.0700
BCX. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .		0.0450
BST . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .		0.2500
BSTZ. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .		0.1920
BUI . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .		0.1210

The fixed amounts distributed per share are subject to change at the discretion of each Trust's Board. Under its Plan, each Trust will distribute all available net income to its shareholders as required by the Internal Revenue Code of 1986, as amended (the "Code"). If sufficient income (inclusive of net income and short-term capital gains) is not earned on a monthly basis, the Trusts will distribute long-term capital gains and/or return of capital to shareholders in order to maintain a level distribution. Each monthly distribution to shareholders is expected to be at the fixed amount established by the Board; however, each Trust may make additional distributions from time to time, including additional capital gain distributions at the end of the taxable year, if required to meet requirements imposed by the Code and/or the Investment Company Act of 1940, as amended (the "1940 Act").

Shareholders should not draw any conclusions about each Trust's investment performance from the amount of these distributions or from the terms of the Plan. Each Trust's total return performance is presented in its financial highlights table.

2	2 0 2 2 B L A C K R O C K S E M I - A N N U A L R E P O R T T O S H A R E H O L D E R S
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Supplemental Information (unaudited) (continued)

The Board may amend, suspend or terminate a Trust's Plan at any time without prior notice to the Trust's shareholders if it deems such actions to be in the best interests of the Trust or its shareholders. The suspension or termination of the Plan could have the effect of creating a trading discount (if the Trust's stock is trading at or above net asset value) or widening an existing trading discount. The Trusts are subject to risks that could have an adverse impact on their ability to maintain level distributions. Examples of potential risks include, but are not limited to, economic downturns impacting the markets, changes in interest rates, decreased market volatility, companies suspending or decreasing corporate dividend distributions and changes in the Code. Please refer to BME, BST and BUI's prospectuses for a more complete description of each Trust's risks.

S U P P L E M E N T A L I N F O R M A T I O N

NM0822U-2398030-3/176

3

The Markets in Review

Dear Shareholder,

The 12-month reporting period as of June 30, 2022 saw the emergence of significant challenges that disrupted the economic recovery and strong financial markets. The U.S. economy shrank in the first quarter of 2022, ending the run of robust growth that followed the reopening of global economies and the development of COVID-19 vaccines. Rapid changes in consumer spending led to supply constraints and elevated inflation, which reached a 40-year high. Moreover, while the foremost effect of Russia's invasion of Ukraine has been a severe humanitarian crisis, the ongoing war continued to present challenges for both investors and policymakers.

Equity prices fell, as persistently high inflation drove investors' expectations for higher interest rates, particularly weighing on relatively high-valuation growth stocks and economically sensitive small-capitalization stocks. While both large- and small-capitalization U.S. stocks fell, declines for small-capitalization U.S. stocks were particularly steep. Both emerging market stocks and international equities from developed markets fell significantly, pressured by rising interest rates and a strengthening U.S. dollar.

The 10-year U.S. Treasury yield (which is inversely related to bond prices) rose notably during the reporting period as increasing inflation drove investors' expectations for higher interest rates. The corporate bond market also faced inflationary headwinds, and increasing uncertainty led to higher corporate bond spreads (the difference in yield between U.S. Treasuries and similarly-dated corporate bonds).

The U.S. Federal Reserve (the "Fed"), acknowledging that inflation is growing faster than expected, raised interest rates three times while indicating that additional large rate hikes were likely. Furthermore, the Fed wound down its bond-buying programs and began to reduce its balance sheet. Continued high inflation and the Fed's statements led many analysts to anticipate that interest rates have significant room to rise before peaking.

Furthermore, the horrific war in Ukraine has significantly clouded the outlook for the global economy, leading to major volatility in energy and metals markets. Sanctions on Russia, Europe's top energy supplier, and general wartime disruption have magnified supply problems for key commodities. We believe elevated energy prices will continue to exacerbate inflationary pressure while also constraining economic growth. Combating inflation without stifling a recovery, while buffering against ongoing supply and price shocks, will be an especially challenging environment for setting effective monetary policy. Despite the likelihood of more rate increases on the horizon, we believe the Fed will err on the side of protecting employment, even at the expense of higher inflation. However, markets have been primed to expect sharp tightening, which could weigh on valuations until central banks begin to tap the brakes.

In this environment, while we favor an overweight to equities in the long-term, the market's concerns over excessive rate hikes from central banks moderate our outlook. Furthermore, the energy shock and a deteriorating economic backdrop in China and Europe are likely to challenge corporate earnings, so we are underweight equities overall in the near-term. We take the opposite view on credit, where higher spreads provide near-term opportunities, while the likelihood of a higher inflation regime leads us to take an underweight stance on credit in the long-term. We believe that investment-grade corporates, U.K. gilts, local- currency emerging market debt, and inflation-protected bonds (particularly in Europe) offer strong opportunities in a six- to twelve-month horizon.

Overall, our view is that investors need to think globally, extend their scope across a broad array of asset classes, and be nimble as market conditions change. We encourage you to talk with your financial advisor and visit blackrock.com for further insight about investing in today's markets.

Sincerely,

Rob Kapito

President, BlackRock Advisors, LLC

4

T H I S

Rob Kapito

President, BlackRock Advisors, LLC

Total Returns as of June 30, 2022

	6-Month	12-Month
U.S. large cap equities	(19.96)%	(10.62)%
(S&P 500 Index)
U.S. small cap equities	(23.43)	(25.20)
(Russell 2000 Index)
International equities
(MSCI Europe, Australasia,	(19.57)	(17.77)
Far East Index)
Emerging market equities	(17.63)	(25.28)
(MSCI Emerging Markets Index)
3-month Treasury bills
(ICE BofA 3-Month	0.15	0.18
U.S. Treasury Bill Index)
U.S. Treasury securities
(ICE BofA 10-Year	(11.34)	(10.94)
U.S. Treasury Index)
U.S. investment grade bonds
(Bloomberg U.S. Aggregate	(10.35)	(10.29)
Bond Index)
Tax-exempt municipal bonds	(8.98)	(8.57)
(Bloomberg Municipal Bond Index)
U.S. high yield bonds
(Bloomberg U.S. Corporate	(14.19)	(12.82)
High Yield 2%
Issuer Capped Index)

Past performance is not an indication of future results. Index performance is shown for illustrative purposes only. You cannot invest directly in an index.

P A G E I S N ONM0822UT P A R T -2398030O F Y O-U4/176RF U N D R E P O R T

Table of Contents
	Page
Supplemental Information .....................................................................................................................................................	2
The Markets in Review ........................................................................................................................................................	4
Option Over-WritingStrategy ..................................................................................................................................................	6
Derivative Financial Instruments ...............................................................................................................................................	6
Semi-Annual Report:
Trust Summary ................................................................................................................................................................	7
Financial Statements:
Schedules of Investments ...................................................................................................................................................	36
Statements of Assets and Liabilities .........................................................................................................................................	124
Statements of Operations ...................................................................................................................................................	127
Statements of Changes in Net Assets .......................................................................................................................................	130
Statements of Cash Flows ..................................................................................................................................................	136
Financial Highlights ...........................................................................................................................................................	141
Notes to Financial Statements .................................................................................................................................................	153
Disclosure of Investment Advisory Agreement and Sub-AdvisoryAgreement .....................................................................................................	165
Additional Information .........................................................................................................................................................	170
Glossary of Terms Used in this Report ..........................................................................................................................................	173

NM0822U-2398030-5/1765