Cassava Sciences : Corporate Presentation – August 2021

We Focus on Alzheimer's disease

August 2021

Forward-Looking Statements & Safe Harbor

This presentation contains forward-looking statements, including statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995, relating to: our strategy and plans; the treatment of Alzheimer's disease; the status of current and future clinical studies with simufilam, including the interpretation of interim analyses of open-label study results; clinical results of our open-label study, including interim analyses; our intention to initiate a Phase 3 clinical program with simufilam in 2021; results of our EOP2 meeting with FDA; our ability to manufacture drug supply for a Phase 3 program; results of a validation study with SavaDx; our ability to expand therapeutic indications for simufilam outside of Alzheimer's disease; expected cash use in future periods; plans to publish results of a Phase 2b study in a peer-reviewed journal; plans to present new clinical data at the 2021 Alzheimer's Association International Conference; verbal commentaries made by our employees; and potential benefits, if any, of the our product candidates. These statements may be identified by words such as "may," "anticipate," "believe," "could," "expect," "forecast," "intend," "plan," "possible," "potential," and other words and terms of similar meaning.

Drug development and commercialization involve a high degree of risk, and only a small number of research and development programs result in commercialization of a product. Our clinical results from earlier-stage clinical trials may not be indicative of full results or results from later-stage or larger scale clinical trials and do not ensure regulatory approval. You should not place undue reliance on these statements or any scientific data we present or publish.

Such statements are based largely on our current expectations and projections about future events. Such statements speak only as of the date of this presentation and are subject to a number of risks, uncertainties and assumptions, including, but not limited to, those risks relating to the ability to conduct or complete clinical studies on expected timelines, to demonstrate the specificity, safety, efficacy or potential health benefits of our product candidates, potential health benefits, if any, of changes in levels of biomarkers, the severity and duration of health care precautions given the COVID-19 pandemic, any unanticipated impacts of the pandemic on our business operations, including those described in the section entitled "Risk Factors" in our Annual Report on Form 10-K for the year ended December 31, 2020 and future reports to be filed with the SEC. The foregoing sets forth many, but not all, of the factors that could cause actual results to differ from expectations in any forward-looking statement. In light of these risks, uncertainties and assumptions, the forward-looking statements and events discussed in this presentation are inherently uncertain and may not occur, and actual results could differ materially and adversely from those anticipated or implied in the forward-looking statements. Accordingly, you should not rely upon forward-looking statements as predictions of future events. Except as required by law, we disclaim any intention or responsibility for updating or revising any forward-looking statements contained in this presentation. For further information regarding these and other risks related to our business, investors should consult our filings with the SEC, which are available on the SEC's website at www.sec.gov.

This presentation may also contain statistical data and drug information based on independent industry publications or other publicly available information. We have not independently verified the accuracy or completeness of the data contained in these publicly available sources of data and information. Accordingly, we make no representations as to the accuracy or completeness of such data or information. You are cautioned not to give undue weight to such data.

The content of this presentation is solely our responsibility and does not necessarily represent the official views of the National Institutes of Health (NIH).

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Cassava Sciences Highlights

• Our goal is to defeat Alzheimer's disease.
• Alzheimer's disease is one of the greatest unmet medical needs, with no disease- modifying medicines.
• Our scientific approach is unique, our clinical data is highly differentiated.
• Our science programs are being developed with scientific and financial support from the National Institutes of Health (NIH).

• We are developing simufilam, a proprietary drug candidate to treat Alzheimer's disease and SavaDx, a blood-based investigational diagnostic.
• Simufilam is Phase 3 ready in 2021.
• Key drivers of our clinical development program:
• • A decade of research in basic biology
  • Clear scientific rationale
  • Published pre-clinical results
  • Well-understoodmechanism of action
  • Clean safety profile
  • Evidence of target engagement in patients
  • Unprecedented CSF biomarker data
  • Phase 2b clinical results
  • Early data on cognition and behavior
  • Successful End-of-Phase 2 meeting with FDA

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Meet the Team

Remi Barbier - Chairman, President & CEO

Nadav Friedmann, PhD/MD - CMO, Board member

Eight FDA drug approvals prior to Cassava Sciences.

Jim Kupiec, MD - Chief Clinical Development

Officer Two FDA drug approvals prior to Cassava Sciences.

Eric Schoen - Chief Financial Officer

Lindsay H. Burns, PhD - SVP Neuroscience

Michael Zamloot - SVP Technical Operations

Four FDA drug approvals prior to Cassava Sciences.

Independent Directors

Sanford Robertson

Founding Partner - Francisco Partners and

Robertson Stephens & Company

Robert Gussin, PhD	Richard Barry
Founding Partner,
Formerly, CSO & Corporate VP, Science	Portfolio Manager,
and Technology, Johnson & Johnson	Eastbourne Capital
Patrick Scannon, MD/PhD
Formerly, Founder & CSO/CMO -
XOMA Corporation	Michael O'Donnell

Partner, Morrison & Foerster LLP

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Introduction to Simufilam

• Simufilam is our proprietary, small molecule (oral) drug candidate to treat Alzheimer's disease (AD) and other neurodegenerative diseases.
• Simufilam binds a single target, has a dual mechanism of action:
• • Reduces neurodegeneration andneuroinflammation.
  • Published preclinical data and mechanism of action studies support simufilam's potential as a disease-modifying drug for AD that also provides symptomatic improvement.

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