Change Healthcare announced a new collaboration with Amazon Web Services, Inc. (AWS) to better assess and improve the effectiveness of interventions and therapies, particularly for underserved and vulnerable populations. The new Data Science as a Service (DSaaS) offering provides de-identified claims data, enhanced with social determinants of health, enabling security and tailored for individual customers seeking to develop and deploy compliant health analytics at scale. Historically, the process of using regulated health data with social determinants is manual, slow, and fraught with compliance challenges. Leveraging the agility, scale, and security of AWS, DSaaS will address those problems by pre-integrating data and deploying automated software that consistently monitors adherence to privacy/compliance obligations to make patient-level integration of de-identified claims, SDOH, behavioral health, and other novel data practical and timely. The Duke University School of Medicine uses DSaaS to explore differences in COVID-19 disease progression as a function of pre-existing conditions and various interventions for different ethnic and socio-economic subgroups. DSaaS offers a compelling operating model to develop unique insight into therapeutic effectiveness while avoiding inequities due to social determinants. Each DSaaS instance is dedicated to a single client, enabling the flexibility to add unique datasets, analytic tools, and methods for a client’s exclusive use. All clients can access Change Healthcare’s de-identified patient-level dataset, spanning diagnoses, care prescriptions, and social determinants across the U.S. healthcare system. All insights, scores, or algorithms developed in DSaaS are monitored for compliance. Compliant results may be exported for operation behind client firewalls or, optionally, within Change Healthcare networks.