The podcast, hosted by
During the interview, Etherington discussed Clene’s work to address the critical unmet medical need relating to neurodegenerative diseases.
“The human nervous system is complex and highly metabolically active. To put it into context, our brain is about two to five percent of our body weight, but it is responsible for about 25 percent of our energy utilization every day. That includes about 20 percent of oxygen consumption and 20-25 percent of glucose utilization. The neurons themselves depend on the mitochondria for all of the energy required to do what we take for granted – moving, walking, talking, eating, chewing and breathing. But with neurodegenerative diseases, including ALS, these essential aspects of life start to be taken away.”
“The World Health Organization predicts that neurodegenerative diseases – amyotrophic lateral sclerosis (ALS), multiple sclerosis, Parkinson’s and others – will become the second-most prevalent cause of death in the next 20 years. So, it’s pretty obvious that a therapeutic breakthrough is urgently needed.
“Most drug development is small molecule chemistry. That’s how it was for basically 100 years. Then, in the last few decades, biologics have taken their place beside small molecule.
Throughout the interview, Etherington continued to discuss CNM-Au8, detailing both current and potential target applications for the nanotherapeutic, before exploring some of the challenges in developing novel therapeutics.
Learn more by listening to the full episode on From Lab to Launch.
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