Compugen Ltd. announced it will present new data on its lead pre-clinical asset COM503, a potential first-in-class anti-IL18BP antibody in an oral presentation at the 38th Annual Meeting of the Society for Immunotherapy of Cancer (SITC), taking place 3-5 November 2023, San Diego, CA. Key data that will be presented at SITC include: Antibody inhibition of IL-18BP prevented tumor growth across multiple mouse tumor models. Antibody induced inhibition of IL-18BP resulted in a significant increase in functional immune-cells such as the effector T-cells and induced a T cell clonal expansion in the tumor, as well as an immune memory response.

Engineered IL-18 cytokine generated peripheral inflammatory responses evident by increased serum cytokines in contrast with an anti-IL-18BP antibody approach which modulated the tumor microenvironment without affecting the periphery. Oral presentation details: Abstract Title: Harnessing natural IL-18 activity through IL-18BP blockade reshapes the tumor microenvironment for potent anti-tumor immune response. Abstract number: 550 Session: Cytokines in Cancer Date: November 3, 2023 Time: 3:30 PM - 5:10 PM PDT.

The data will also be presented as a poster on November 4, 2023.