In accordance with the Merger Agreement, at the effective time of the Merger, each of Mark A. Goldsmith, Jigar Raythatha, James E. Audia, Scott Braunstein, Steven L. Hoerter, Richard Levy, and Elizabeth G. Tréhu resigned from the board of directors of Constellation. These resignations were in connection with the Merger and not as a result of any disagreements between Constellation and the resigning individuals on any matters relating to Constellation’s operations, policies or practices. In accordance with the Merger Agreement, at the effective time of the Merger, Karen Valentine resigned as Chief Legal Officer and General Counsel of Constellation, Patrick Trojer resigned as Chief Scientific Officer of Constellation, and Jeffrey Humphrey resigned as Chief Medical Officer of Constellation.