E therapeutics : Interim Results for the financial year 2023/2024

Interim Results for the financial year 2023/2024

Interim results for the six months to 31 July 2023

Six months of progress with positive proof-of-concept data generated with lead GalOmic™ RNAi assets in cardiometabolic disease and haemophilia

Continued integration of generative artificial intelligence into HepNet™

London, UK, 26 October 2023 - e-therapeutics plc (AIM: ETX; OTCQX; ETXPF), a company integrating computational power and biological data to discover life-transforming RNAi medicines, announces its unaudited interim results for the six months to 31 July 2023.

Operational Highlights

• Continued growth and rapid advancement of GalOmic™ RNAi therapeutics against target genes discovered using our HepNet^TM computational platform, including preclinical programs in cardiometabolic and metabolic disease, haemophilia, and two further undisclosed programs.
• Generated positive proof-of-concept data for ETX-291 in cardiometabolic disease and ETX-148 in haemophilia, demonstrating disease-modifying potential of HepNet™ identified targets.
• Increased pool of novel targets identified and assessed in silico by HepNet™, ensuring a continual supply of in-house preclinical programs and a variety of partnering opportunities spanning a broad range of therapeutic areas.
• Continued validation of HepNet™, including our hepatocyte-specific knowledge graph, proprietary target identification approaches, and siRNA (short interfering RNA) construct design capabilities.
• Advanced projects developing and implementing generative artificial intelligence ("AI") including large language models ("LLMs") across ETX processes and systems, further enhancing computational capabilities, and transforming HepNet™ into a dynamic knowledge resource.
• Continued expansion of AI approaches, enabling the transformation of siRNA construct design and selection to reduce timelines and associated costs dramatically.
• Sustained intellectual property ("IP") activity continued, with priority forming patent applications filed on three new inventions, and consolidated international filing programs for eight inventions, all arising from the Company's proprietary GalNAc-siRNA technology, GalOmic™.
• Strong progress made in immuno-oncology collaboration with iTeos Therapeutics, Inc. ("iTeos"), with continued delivery against pre-agreed milestones.

Post Period Highlights

Effective 20 September 2023, Timothy Bretherton assumed the role of Chief Financial Officer (non-board). Michael Bretherton stepped down from his role as interim CFO and will now focus on his role as a Non-Executive Director of the Company.

Financial Highlights

• Revenue of £0.2 million (H1 2022: £0.3 million)
• R&D spend of £5.3 million (H1 2022: £3.1 million)
• Operating loss for the period of £7.0 million (H1 2022 loss: £4.6 million)
• Loss after tax for the period of £5.6 million (H1 2022 loss: £3.8 million)
• Cash and cash equivalents as at 31 July 2023 of £24.8 million (31 January 2023: £31.7 million)
• R&D tax credit receivable as at 31 July 2023 of £2.5 million (31 January 2023: £1.5 million)
• Headcount (excluding Non-Executive Directors) as at 31 July 2023 of 34 (31 January 2023: 38)

Ali Mortazavi, Chief Executive Officer of e-therapeutics, commented:

"Despite a severe macroeconomic climate, we have made significant progress during the past six months. It is a tribute to our team that we have been able to translate our computational analyses into tangible assets, generating compelling preclinical data at a fraction of the R&D spend of any competitor. We look forward to showcasing additional data from our preclinical pipeline in the near future.

"It has only been six months since we began incorporating generative AI into our processes and projects, but the significant impact of these technologies throughout ETX is already apparent. Through this work, we continue to address directly the long, expensive, and risky product lifecycle of drug discovery, solidifying ourselves as one of the leading companies in the emerging TechBio sector. A year ago, generative AI technologies did not exist. Now, we are integrating them into every aspect of our drug development process, allowing us to develop our life-transforming RNAi medicines at pace. As we continue to leverage the most cutting-edge computation, I look forward to the future with confidence."

The information contained within this announcement is deemed by the Company to constitute inside information as stipulated under the Market Abuse Regulations (EU) No. 596/2014 ('MAR') which has been incorporated into UK law by the European Union (Withdrawal) Act 2018. Upon the publication of this announcement via Regulatory Information Service ('RIS'), this inside information is now considered to be in the public domain.

Chief Executive's Statement

During the past six months, we have concluded the successful transition into a proven RNAi biotech company. Our lead assets in cardiometabolic disease and haemophilia have progressed to preclinical proof-of-concept experiments, validating our HepNet™ computational platform, our GalOmic™ chemistry platform, and delivering proof in support of our goal of Computing the Future of Medicine™.

While we continue to build our in-house pipeline of assets, we are progressing HepNet™ into the central nexus within e-therapeutics. By leveraging generative artificial intelligence ("AI") and large language model ("LLM") advances, we have built on the validated technology and data resources in HepNet™ and are beginning to unlock next-level predictive power in a truly seamless system. This transformation will continue to deliver novel therapeutics at an unprecedented scale, increasing the pace of target identification and dramatically reducing the time and cost of developing life-transforming medicines.

GalOmic™ RNAi Platform and Continued Execution of Therapeutic Pipeline

We continue to progress our therapeutic pipeline, with five assets currently in preclinical studies across a range of therapeutic areas, including cardiometabolic disease and haemophilia. During the past six months, we have generated positive proof-of-concept data for ETX-291 in cardiometabolic disease and ETX-148 in haemophilia, underscoring the robustness of the GalOmic™ platform and validating HepNet™'s ability to identify novel genes with therapeutic potential. These proof-of-concept data are underpinned by the silencing profile of our siRNA platform. GalOmic™ constructs have demonstrated potent and durable knockdown of target mRNA expression of therapeutically relevant targets in vivo, supporting infrequent dosing.

ETX-291 for the Treatment of Cardiometabolic Disease

Cardiometabolic diseases are a leading cause of death and encompass multiple conditions including obesity, cardiovascular disease, and Type 2 diabetes. ETX-291 targets a gene with human genetic evidence of disease-modifying benefit. In preclinical studies in a representative disease model, ETX-291 impacts multiple cardiometabolic disease drivers resulting in a pleiotropic benefit and highlighting its potential to treat a broad range of cardiometabolic indications.

ETX-148 for the Treatment of Haemophilia

ETX-148 is our preclinical pan-haemophilia asset. We have generated data that suggests it is safe, effective, and able to address a key remaining unmet need in haemophilia: protection from joint bleeds. Histological data from a preclinical joint bleed model suggests ETX-148 can protect against bleed-induced joint damage. Importantly, this protection is achieved without an increased risk of thrombosis, which has been characterised in a variety of safety experiments.

ETX-291 and ETX-148 are due to complete preclinical proof-of-concept studies by the end of the year and we are looking forward to presenting further details of our preclinical data packages in the near future. Additionally, we continue to add to our pool of novel targets, ensuring our early pipeline is populated and generating additional partnering opportunities.

Non-dilutive funding opportunities via collaborations and partnerships remain a key component of the Company's strategy. Successfully demonstrating preclinical proof-of-concept for our first RNAi assets is fuelling partnering and out-licensing conversations both for individual assets and platform access, striking a balance between preclinical assets to partner and assets that we will progress to early clinical trials to reach a more significant value inflection point.

HepNet™ and Integration of Large Language Models

We continue to strengthen, innovate, and validate HepNet™, the most comprehensive hepatocyte data and analytics resource in the world. This has included the generation of positive proof-of-concept data for our in-house GalOmic™ pipeline programs, validating HepNet™'s ability to reliably identify novel gene targets and design potent siRNA constructs. Furthermore, we have continued to expand our knowledgebase, initiating partnerships that will provide access to proprietary data assets that will support disease-related process and target discovery.

We are fully embracing generative AI and LLMs by creating specialised LLM "agents" and transforming HepNet™ into a dynamic knowledge resource. Over the past six months, this ambitious agenda has driven design and development of infrastructure and model development and refinement. Over the coming months it will deliver a unifying framework driving every aspect of our pipeline, solidifying e-therapeutics' position as a global leader in AI-driven drug development.

Our projects include our "Straight to In Vivo" efforts, which will allow us to bypass in vitro screening and move straight to in vivo models. This will dramatically reduce timelines and costs associated with identifying optimal siRNA constructs to silence any hepatocyte-expressed target gene. We ultimately aim to create a robust pipeline and business model leveraging the full potential of Generative AI and LLM to continue breaking new ground in drug discovery, creating novel therapeutics, and improving patient outcomes.

Intellectual Property

The Company continues to execute its very active IP strategy that is indicative of both the high volume of novel innovations being generated and the critical importance ETX attributes to protecting its inventions. The patent applications filed over the period 31 January 2023 to 31 July 2023 cover eleven inventions arising from the Company's innovation around novel target ideas, novel siRNA therapeutics, and novel siRNA chemistries.

Partnerships and Collaborations

We continue to deliver on our collaboration with iTeos Therapeutics, leveraging our unique computational methodology to enable the discovery of highly differentiated novel immuno-oncology therapeutics. The work is progressing well against pre-defined plans and milestones, successfully passing decision gates. As well as receiving near-term cash payments material to the revenue of the Company, we are eligible to receive undisclosed milestone payments through preclinical and clinical development, in addition to regulatory milestones, per programme.

Organisation

ETX continues to invest in and attract leading industry talent, adding to an existing world class multi-disciplinary team of experts in computational biology and RNAi therapeutics. This is exemplified by our recent hires in the USA, driven by our desire to hire the best talent and resulting in a lean presence on the East Coast, a major biotech hub.

The team has worked hard to deliver the progress highlighted in this statement and I should like to thank them for their continued commitment and dedication in helping ETX to deliver on its strategy and key objectives.

At a Board level, there is an open position for an additional independent NED to broaden the Board experience further and adhere to best practice corporate governance guidelines.

Post Period

On 20 September 2023, ETX announced that Michael Bretherton had stepped down from his role as interim CFO and will now focus on his role as a Non-Executive Director of the Company. Timothy Bretherton, Director of Finance and Operations, assumed the CFO role (non-board) with immediate effect.

Outlook

Despite a severe macroeconomic climate, we have made significant progress during the past six months. It is a tribute to our team that we have been able to translate our computational analyses into tangible assets, generating compelling preclinical data at a fraction of the R&D spend of any competitor. We look forward to showcasing additional data from our preclinical pipeline in the near future.

It has only been six months since we began incorporating generative AI into our processes and projects, but the significant impact of these technologies throughout ETX is already apparent. Through this work, we continue to address directly the long, expensive, and risky product lifecycle of drug discovery, solidifying ourselves as one of the leading companies in the emerging TechBio sector. A year ago, generative AI technologies did not exist. Now, we are integrating them into every aspect of our drug development process, allowing us to develop our life-transforming RNAi medicines at pace. As we continue to leverage the most cutting-edge computation, I look forward to the future with confidence.

Ali Mortazavi

Chief Executive Officer

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