e-Therapeutics plc ("e-Therapeutics" or the "Company") Change of Nominated Adviser and Broker Oxford and Newcastle, UK, 17 September 2015 - e-Therapeutics plc (AIM: ETX), the drug discovery and development company, has appointed Numis Securities Limited as its Nominated Adviser and Broker with immediate effect.

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Contacts: e-Therapeutics plc

Malcolm Young, CEO / Steve Medlicott, Finance Director
Tel: +44 (0)1993 883 125 www.etherapeutics.co.uk

Numis Securities Limited

Michael Meade / Freddie Barnfield (Nominated Adviser) Graeme Summers / James Black (Corporate Broking)
Tel: +44 (0) 20 7260 1000

Instinctif Partners

Melanie Toyne Sewell / Jayne Crook
Tel: +44 (0) 20 7457 2020
Email: e-therapeutics@instinctif.com

About e-Therapeutics plc

e-Therapeutics is a drug discovery and development company with a proprietary platform in network pharmacology, an innovative approach to drug discovery based on advances in network science and chemical biology. e-Therapeutics' platform is generating more potent, selective and diverse molecules at much higher yields than is reported for conventional drug discovery. The Company's discovery and development activity addresses age-related diseases, including cancer and
central nervous system disorders, and it is fully funded to advance its programme into 2019, including phase II clinical data and multiple regulatory submissions.
e-Therapeutics has a phase IIb clinical stage drug candidate for major depressive disorder, ETS6103. It has a phase Ib clinical stage candidate in hepatocellular and pancreatic cancer, ETS2101. The company has a variety of preclinical stage assets, including ETX1153c, a functionally resistance-less antibiotic; ETS2300, telomerase inhibition in anti-cancer; ETS3100, small molecule anti-TNFα and ETS2400, Hedgehog pathway inhibition.
e-Therapeutics is based at sites in Oxford and Newcastle, UK. For more information about the
Company, please visit www.etherapeutics.co.uk.

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