“We are thrilled
“This exciting research demonstrates that Alt-R A.s. Cas12a (Cpf1) Ultra is a robust gene editing tool while maintaining our desired on-target specificity, making it ideal for complex genomic editing applications,” said
The published results detail a directed evolution in bacteria to identify a highly active AsCas12a mutant, Alt-R A.s. Cas12a (Cpf1) Ultra, and demonstrate the variant’s superior on-target editing efficacy compared to Cas9 and AsCas12a. The paper summarizes several experiments of Alt-R A.s. Cas12a (Cpf1) Ultra that demonstrated dramatically elevated knock-out and knock-in efficiency in both cancer cell lines and in human primary cells such as hematopoietic stem and progenitor cells (HSPCs), induced pluripotent stem cells (iPSCs), T cells, and natural killer (NK) cells. Overall, the results support further research for the use of Alt-R A.s. Cas12a (Cpf1) Ultra as an advanced CRISPR nuclease with significant potential future applications.
About
As a leading genome editing company, Editas Medicine is focused on translating the power and potential of the CRISPR/Cas9 and CRISPR/Cas12a (also known as Cpf1) genome editing systems into a robust pipeline of treatments for people living with serious diseases around the world. Editas Medicine aims to discover, develop, manufacture, and commercialize transformative, durable, precision genomic medicines for a broad class of diseases. For the latest information and scientific presentations, please visit www.editasmedicine.com.
About IDT
Editas Medicine Forward-Looking Statements
This press release contains forward-looking statements and information within the meaning of The Private Securities Litigation Reform Act of 1995. The words "anticipate," "believe," "continue," "could," "estimate," "expect," "intend," "may," "plan," "potential," "predict," "project," "target," "should," "would," and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. The Company may not actually achieve the plans, intentions, or expectations disclosed in these forward-looking statements, and you should not place undue reliance on these forward-looking statements. Actual results or events could differ materially from the plans, intentions and expectations disclosed in these forward-looking statements as a result of various factors, including: uncertainties inherent in the initiation and completion of preclinical studies and clinical trials and clinical development of the Company’s product candidates; availability and timing of results from preclinical studies and clinical trials; whether interim results from a clinical trial will be predictive of the final results of the trial or the results of future trials; expectations for regulatory approvals to conduct trials or to market products and availability of funding sufficient for the Company’s foreseeable and unforeseeable operating expenses and capital expenditure requirements. These and other risks are described in greater detail under the caption “Risk Factors” included in the Company’s most recent Annual Report on Form 10-K, which is on file with the Securities and Exchange Commission, as updated by the Company’s subsequent filings with the
Editas Medicine Contacts: MediaCristi Barnett (617) 401-0113 cristi.barnett@editasmed.com InvestorsRon Moldaver (617) 401-9052 ir@editasmed.com IDT Contacts: Media IDT Public Relations 800-328-2661 (USA &Canada ) +1 319-626-8400 (outsideUSA ) idtpr@idtdna.com www.idtdna.com
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