ILLUMINA, INC.
'The data we are presenting at AACR continue to support the potential of GRAIL's Methylation Platform to transform cancer care and the potential benefits of population-scale asymptomatic (or early) cancer detection,' said
In the MCED setting, GRAIL is honored to present 3 oral presentations at AACR: Demonstrating the first real-world evaluation of repeat MCED / Galleri testing showing the potential value of adding repeat MCED screening. The timeframe for repeat testing occurred 10-18 months from initial MCED testing.
Exhibiting 4-year overall survival follow-up demonstrating the prognostic significance of detecting cancer with a methylation-based cfDNA platform like Galleri.
Illustrating data demonstrating the power of Galleri to preferentially detect high grade, clinically significant prostate cancer over indolent cases.
In the precision oncology setting, GRAIL will discuss the adaptability of its Methylation Platform in identifying cancer histological and molecular subtypes through blood samples.
Oral Presentations
Title: Early Real-World Experience with Repeat Multi-Cancer Early Detection (MCED) Testing
Abstract Number: #3891
Session Category: Clinical Research
Session Title: Application of Real-World Evidence to Cancer Care
Date/Time:
Location: Room 6 CF - Upper Level -
Title: A Targeted Methylation-Based Multi-Cancer Early Detection Blood Test Preferentially Detects High-Grade Prostate Cancer and Minimizes Overdiagnosis
Abstract Number: #1264
Session Category: Prevention / Early Detection / Interception
Session Title: Multi-Cancer Early Detection Testing: Where Are We
Date/Time:
Location:
Title: Prognostic Significance of Blood-Based Multi-Cancer Detection in Cell-Free DNA: 4-Year Outcomes Analysis
Abstract Number: #3895
Session Category: Clinical Research
Session Title: Early Detection and Progression Biomarkers
Date/Time:
Location: Ballroom 6 B - Upper Level -
Poster Sessions
Title: PATHFINDER 2: A Prospective Study to Evaluate Safety and Performance of a Multi-Cancer Early Detection Test in a Population Setting
Abstract Number: #4784
Session Category: Prevention / Early Detection / Interception
Session Title: Population-Based Screening
Date/Time:
Location: Poster Section 32
Title: Identification of Cancer Subtypes with a ctDNA-based Targeted Methylation Assay
Abstract Number: #7566
Session Category: Clinical Research
Session Title: Molecular Biology in Clinical Oncology: Characterizing and Modulating Epigenetics and Gene Expression
Date/Time:
Location: Poster Section 43
Title: Most Cancer Deaths are Unaddressed by Current Screening Paradigms
Abstract Number: #6075
Session Category: Prevention / Early Detection / Interception
Session Title: Biomarker-Based Screening
Date/Time:
Location: Poster Section 31
Title:
Abstract Number: #LB107
Session Category: Clinical Research
Session Title:
Date/Time:
Location: Poster Section 51
About GRAIL
GRAIL is a healthcare company whose mission is to detect cancer early, when it can be cured. GRAIL is focused on alleviating the global burden of cancer by using the power of next-generation sequencing, population-scale clinical studies, and state-of-the-art machine learning, software, and automation to detect and identify multiple deadly cancer types in earlier stages. GRAIL's targeted methylation-based platform can support the continuum of care for screening and precision oncology, including multi-cancer early detection in symptomatic patients, risk stratification, minimal residual disease detection, biomarker subtyping, treatment and recurrence monitoring. GRAIL is headquartered in
About Galleri
The Galleri multi-cancer early detection test is a new proactive tool to screen for cancer. It is a blood test that can help screen for many of the deadliest cancers that don't have recommended screening today, such as pancreatic, esophageal, ovarian, and liver. The Galleri test can identify DNA shed by cancer cells (unique 'fingerprints') to screen for some of the deadliest cancers before they become symptomatic, when cancer may be more easily treated and potentially curable. The Galleri test provides direction to doctors on the cancer's origin and helps guide next steps for diagnosis. The Galleri test requires a prescription from a licensed healthcare provider and should be used in addition to recommended cancer screenings such as mammography, colonoscopy, prostate-specific antigen (PSA) test, or cervical cancer screening. It is recommended for people over the age of 50, or those with an elevated risk for cancer due to genetics, family history, environmental exposure, or other risk factors.
Important Galleri Safety Information
The Galleri test is recommended for use in adults with an elevated risk for cancer, such as those aged 50 or older. The Galleri test does not detect all cancers and should be used in addition to routine cancer screening tests recommended by a healthcare provider. Galleri is intended to detect cancer signals and predict where in the body the cancer signal is located. Use of Galleri is not recommended in individuals who are pregnant, 21 years old or younger, or undergoing active cancer treatment.
Results should be interpreted by a healthcare provider in the context of medical history, clinical signs and symptoms. A test result of 'Cancer Signal Not Detected' does not rule out cancer. A test result of 'Cancer Signal Detected' requires confirmatory diagnostic evaluation by medically established procedures (e.g., imaging) to confirm cancer.
If cancer is not confirmed with further testing, it could mean that cancer is not present or testing was insufficient to detect cancer, including due to the cancer being located in a different part of the body. False-positive (a cancer signal detected when cancer is not present) and false-negative (a cancer signal not detected when cancer is present) test results do occur. Rx only.
Contact:
Email: pr@grail.com
Email: ir@grail.com
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