ImMAGE Biotherapeutics announced that its immunotherapy successfully passed early toxicology and efficacy studies. The company is harnessing the power of the immune system to target a specific protein, MAGE A, in an effort to find a better treatment for triple negative breast cancer. After 4 weeks of treatment in transgenic mice, the lead candidate was able to show very little toxicity in a full toxicology report of various organs. Cytotoxic T-cells were removed from the mice to test the efficacy ex vivo to check for targeted response against MAGE-A positive cancer cells. There was a significant increase in cell death of MAGE-A positive tumor cells compared to MAGE-A negative tumor cells. ImMAGE Biotherapeutics is in the process of conducting preclinical development and plans to file an IND in 2018 to start phase 1 clinical trials. ImMAGE Biotherapeutics targets to move the candidate into human trials in late 2018/early 2019.