Impel Neuropharma Inc. announced that the U.S. Food and Drug Administration (FDA) has notified the Company that it may proceed with its clinical investigation of INP104, a novel, dihydroergotamine (DHE) product dosed via Impel's proprietary Precision Olfactory Delivery, or POD®, intranasal delivery device for the treatment of acute migraine. The notice to proceed was received following Impel's submission of an investigational new drug (IND) application for this program. Impel expects to commence enrollment in the pivotal Phase 3 study evaluating the safety and tolerability of long-term, intermittent use of INP104 for the treatment of acute migraine headache in second half 2018.