Item 5.02 Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

On March 13, 2022, Grady Burnett, a member of the Board of Directors (the "Board of Directors") of Kaleido Biosciences, Inc. (the "Company") tendered his resignation from the Board of Directors. In connection with his resignation from the Board of Directors, Mr. Burnett also resigned from all committees of the Board of Directors on which he served, including the Nominating and Corporate Governance Committee and the Audit Committee of the Board. The decision by Mr. Burnett to resign was not the result of any disagreements with the Board of Directors or management of the Company.

On March 15, 2022, Geoffrey von Maltzahn, and member of the Board of Directors, tendered his resignation from the Board of Directors. At the time of his resignation, Dr. Maltzahn did not serve on any committees of the Board of Directors. The decision by Dr. Maltzahn to resign was not the result of any disagreements with the Board of Directors or management of the Company.

Theo Melas-Kyriazi, an executive partner of Flagship Pioneering, remains as the Chairman of the Board of Directors.

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits:



Exhibit No.   Description

104           Cover Page Interactive Data File (embedded within the Inline XBRL
              document).

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