On March 13, 2022, Grady Burnett, a member of the Board of Directors of Kaleido Biosciences, Inc. tendered his resignation from the Board of Directors. In connection with his resignation from the Board of Directors, Mr. Burnett also resigned from all committees of the Board of Directors on which he served, including the Nominating and Corporate Governance Committee and the Audit Committee of the Board. On March 15, 2022, Geoffrey von Maltzahn, and member of the Board of Directors, tendered his resignation from the Board of Directors.

At the time of his resignation, Dr. Maltzahn did not serve on any committees of the Board of Directors.