On December 6, 2021, Ignacio Nunez informed the Board of Directors of Kiromic Biopharma, Inc. that he was resigning his position as Chief Manufacturing and Operating Officer immediately due to personal reasons. Mr. Nunez’s resignation did not involve a disagreement with the Registrant on any matter relating to the Registrant’s operations, policies or practices. On December 8, 2021, Mr. Nunez and the Registrant entered into a Separation Agreement dated as of December 6, 2021 in connection with his resignation.