On December 6, 2022, Dr. Karen Reeves informed the Board of Directors of Kiromic BioPharma, Inc. that she was resigning her position as a director of the Registrant, effective immediately. Dr. Reeves also ceased to be a member of the Nominating and Corporate Governance Committee, and the Compensation Committee of the Board. Dr. Reeves' resignation did not involve a disagreement with the Registrant on any matter relating to the Registrant's operations, policies or practices.