On August 11, 2022, Dr. Monica Bertagnolli, a director of the Leap Therapeutics, Inc., informed the Company that she will be resigning as a director, effective August 12, 2022, as a result of her appointment as the 16th Director of the National Cancer Institute (NCI) by the Biden administration. Dr. Bertagnolli's departure is not a result of any disagreement with the Company relating to the Company's operations, policies or practices.