Medigen Vaccine Biologics Corporation announced the resignation of Chang, Ming-Cheng as Independent Director. Date of occurrence of the change: March 8, 2023; Elected or changed position: independent director; Title and name of the previous position holder: Chang, Ming-Cheng; Resume of the previous position holder: The past experience was the accountant of PricewaterhouseCoopers Taiwan & head of reputation and risk. Currently serving as the Chairman of the Auditing Standards Committee of the Republic of China.

Circumstances of change: resignation; Reason for the change: personal career planning and Any other matters that need to be specified: The company received the resignation letter of the independent director on March 8, 2023, and resigned from the positions of the company's independent director, member of the audit committee and member of the remuneration committee, and the effective date is March 8, 2023.