As previously disclosed, on January 24, 2023, the Board of Directors (the “Board”) of Metacrine, Inc. (the “Company”) appointed Michael York, the Company's Chief Business Officer, to the additional positions of President, Chief Executive Officer and Secretary, and designated Mr. York as the Company's principal executive officer, in each case effective as of February 1, 2023. Mr. York continues to serve as the Company's Chief Business Officer, Treasurer, principal financial officer and principal accounting officer.