On October 8, 2019, Timothy L. Maness, the Chief Accounting Officer, principal financial officer and principal accounting officer of Milestone Pharmaceuticals Inc. (the 'Company') notified the Company of his decision to resign from the Company, including any positions held with the Company, effective October 31, 2019 (the 'Effective Date'). Following the Effective Date, the Company will be eliminating the position of Chief Accounting Officer. On October 11, 2019, the Board of Directors of the Company appointed Amit Hasija, the current Chief Financial Officer and Executive Vice President of Corporate Development of the Company, as the principal financial officer and principal accounting officer of the Company, effective October 11, 2019.