EXOFASTTRACK is a collaborative project focused on accelerating the development of multiple therapeutic exosomes for rapid clinical evaluation. Mainly isolated from stem cells, which are known for their regenerative and anti-inflammatory properties, exosomes are considered to have opened new horizons in cell therapy and Advanced Therapy Medicinal Products (ATMPs). The main function of exosomes is to act as intercellular messengers over long distances. Therapeutic exosomes are based on very large-scale reproduction, several billion copies, of an intercellular message specific to the producing cells, e.g. stem cells, in the lab. In addition, it is possible to modify the “therapeutic message” by loading a therapeutic agent specific to the targeted disease or “loading,” substantially enhancing their field of application. The development of new automated technologies for both the production and loading of exosomes uses a ‘low-footprint’ approach, with the aim of significantly reducing the surface area required to implement these processes as well as lowering the costs of manufacturing and energy consumption, which reduces the environmental footprint in terms of greenhouse gas emissions.
Orgenesis’ role within the consortium is to develop a therapeutic candidate composed of exosomes derived from adipose tissue MSC (Human Mesenchymal Stem/Stromal Cells) loaded with an active compound and/or fused with Bioxomes™ to treat skin ulcers.
The production of exosomes will be conducted in partnership with Cilyx and ExoXpert and through automated and controlled modules within GMP facilities. Functional characterization and quality control of the exosomes and exosome-producing cells in microfluidic droplets will be performed in partnership with LiveDrop. Functional evaluation will be performed by ULB-CMMI with the goal of characterization of the exosomes by pre- and post-loading cryo-electron microscopy and tissue imaging for detection of exosomes as well as in vivo and ex vivo bioluminescence imaging methods.
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