On October 4, 2019, Steven Lo notified Puma Biotechnology, Inc. of his decision to resign as the Company's Chief Commercial Officer, effective October 18, 2019. Mr. Lo has informed the Company that he has accepted a position as the Chief Executive Officer of a company that is preparing for commercialization and focusing on the development of therapies for the central nervous system. Mr. Lo's responsibilities will be assumed by the Company's existing commercial team while the Company initiates a search for a replacement.