Race Oncology highlights impressive bisantrene clinical data
November 07, 2023 at 12:16 pm EST
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Race Oncology Ltd (ASX:RAC) executive director Dr Pete Smith discusses with Proactive impressive Phase 2 clinical trial results from its Acute Myeloid Leukaemia (AML) clinical trial. The interim clinical results are from an ongoing investigator-initiated Phase 2 trial of bisantrene in combination with fludarabine and clofarabine in relapsed or refractory acute myeloid leukaemia patients. Administered over four days, the drug combination induced a clinical response in 40% of evaluable patients with five patients receiving a potentially curative stem cell transplant.
“To see such meaningful clinical responses in a group that would typically be receiving palliative care is striking," said Smith.
"It is also encouraging that the safety profile was manageable, even for this advanced patient population.
"These are highly positive outcomes in a heavily pretreated patient population.”
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Proactive Investors
Gregg Castano
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gregg.castano@newsdirect.com
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Race Oncology Limited is an Australia-based precision oncology company with a Phase II/III cancer drug called Zantrene. Zantrene is a potent small molecule inhibitor of the Fatso/Fat mass and obesity associated (FTO) protein. The Company is exploring the use of Zantrene as a new therapy for melanoma and clear cell renal cell carcinoma (kidney cancer), which are both frequent FTO-driven cancers. Zantrene (bisantrene dihydrochloride) is a small molecule anti-cancer drug which has clinical and preclinical efficacy as both a low dose, highly targeted precision oncology agent and a cardio-protective chemotherapeutic. The Company also has clinical data for the use of Zantrene as a chemotherapeutic agent with reduced cardiotoxicity in acute myeloid leukemia (AML), breast and ovarian cancers and is investigating its use in these areas.