Senhwa Biosciences, Inc. announced that their first patient has been successfully dosed, in a Phase 1b clinical study of Pidnarulex as a potential treatment for solid tumors with Homologous Recombination (HR) gene mutations, at the Princess Margaret Cancer Centre in Toronto, Canada. This new Phase 1b open-label, multi-center Expansion study (in both US and Canada) was designed to determine a tolerable dose of Pidnarulex in patients with selected solid tumors with BRCA1/2, PALB2, and other HR gene mutations. This dose will be used in future Phase II trials. In a previous Phase 1 trial, Pidnarulex demonstrated clinically significant and lasting benefits in patients with specific tumor biomarkers, such as BRCA1/2, and PALB2 mutations and that were also resistant to platinum and other chemotherapeutics. This past May, the American College of Medical Genetics and Genomics (ACMG) issued new guidance for patients and doctors, advising that individuals with PALB2 mutations be surveilled similarly to individuals with BRCA mutations. The experts have identified the PALB2 mutation as the third most important breast cancer gene after BRCA1 and BRCA2 mutations, as it also increases a patient's risk of developing ovarian and pancreatic cancer.