Item 1.01 Entry Into a Material Definitive Agreement.

On September 22, 2021, Synlogic, Inc. (the "Company") entered into an underwriting agreement (the "Underwriting Agreement") with Jefferies LLC and SVB Leerink LLC, as representatives of the several underwriters named therein (the "Underwriters"), relating to the underwritten public offering of 15,000,000 shares of the Company's common stock, par value $0.001 per share (the "Offering"). The price to the public in the Offering was $3.00 per share. The net proceeds to the Company from the Offering are expected to be $42,300,000, after deducting underwriting discounts and commissions and before deducting other estimated offering expenses payable by the Company. The Offering is scheduled to close on or about September 27, 2021, subject to customary closing conditions. In addition, under the terms of the Underwriting Agreement, the Company granted the Underwriters an option, exercisable for 30 days, to purchase up to 2,250,000 additional shares of common stock at the initial public offering price.

The Underwriting Agreement contains customary representations, warranties and agreements by the Company, customary conditions to closing, indemnification obligations of the Company and the Underwriters, including for liabilities under the Securities Act of 1933, as amended (the "Securities Act"), other obligations of the parties and termination provisions.

The Offering was made pursuant to the Company's effective registration statement on Form S-3 (Registration Statement No. 333-258151) previously filed with the Securities and Exchange Commission ("SEC") and a related prospectus supplement and accompanying prospectus. The Underwriting Agreement is filed as Exhibit 1.1 to this report and is incorporated herein by reference. The foregoing description of the terms of the Underwriting Agreement does not purport to be complete and is qualified in its entirety by reference to such exhibit. A copy of the opinion of Mintz, Levin, Cohn, Ferris, Glovsky & Popeo, P.C. relating to the legality of the issuance and sale of the shares in the Offering is attached as Exhibit 5.1 hereto.

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Item 8.01 Other Events.

On September 22, 2021, the Company issued a press release announcing that it had commenced the Offering. On September 22, 2021, the Company issued a press release announcing that it had priced the Offering. Copies of these press releases are attached as Exhibits 99.1 and 99.2 hereto, respectively, and the information contained therein is incorporated herein by reference.

This report contains "forward-looking statements" within the meaning of Section 27A of the Securities Act and Section 21E of the Securities Exchange Act of 1934, as amended, including statements regarding the Company's expectations with respect to the Offering, including its ability to complete the Offering and its expected and intended use of proceeds from the Offering. These and any other forward-looking statements in this report are based on management's current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. These risks and uncertainties include, but are not limited to, the risks and uncertainties associated with market conditions and the satisfaction of customary closing conditions related to the proposed offering, as well as risks and uncertainties detailed in the Company's periodic filings with the SEC, including but not limited to the Company's Form 10-K for the year ended December 31, 2020, and from time to time the Company's other investor communications. The Company is providing the information in this report as of this date and does not undertake any obligation to update any forward-looking statements contained in this report as a result of new information, future events or otherwise, except to the extent required by law.

Item 9.01 Financial Statements and Exhibits.




(d) Exhibits



Exhibit
  No.                                    Description

1.1           Underwriting Agreement, dated September 22, 2021, among Synlogic,
            Inc. and Jefferies LLC and SVB Leerink LLC, as representatives of the
            several underwriters named therein.

5.1           Opinion of Mintz, Levin, Cohn, Ferris, Glovsky & Popeo, P.C.

23.1          Consent of Mintz, Levin, Cohn, Ferris, Glovsky & Popeo, P.C.
            (included in Exhibit 5.1)

99.1          Press Release, dated September 22, 2021, related to the launch of
            the offering.

99.2          Press Release, dated September 22, 2021, related to the pricing of
            the offering.

104         Cover Page Interactive Data File (embedded within the Inline XBRL
            document)

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