Twist Bioscience Corporation announced the launch of a new Human Pangenome Spike-in for the Twist Exome 2.0 panel developed to enable researchers to detect a more complete view of genetic variation during whole exome sequencing (WES). The Human Pangenome Reference Consortium (HPRC) is a project funded by the National Human Genome Research Institute (NHGRI) that has the objective to sequence and assemble complete telomere-to-telomere genomes from individuals from diverse populations into a new type of reference in order to better represent the genomic landscape of diverse human populations. The updated HPRC reference standard includes samples from 24% African ancestry, 30% Americas, 18% East Asia and 28% South Asia.

The Twist Human Pangenome Spike-in Panel targets 2.5 Mb of pangenome variants and can be spiked into the Twist Exome 2.0 to target more than 94% of the novel pangenome variants affecting coding sequences in the exome.