TYME Technologies, Inc. announced the availability of the poster abstract, “SM-88, D/L-alpha-metyrosine, is a novel anti-cancer agent in estrogen receptor positive breast cancer,” which was submitted by researchers from Georgetown University. The abstract will be presented by Dr. Ayesha Shajahan-Haq at the American Association for Cancer Research (AACR) Annual Meeting 2022 in New Orleans, LA. Dr. Shajahan-Haq, PhD is an Assistant Professor in the Department of Tumor Biology at Georgetown University, and her research focuses on resistance mechanisms in breast cancer.

Through the OASIS breast cancer study, TYME is collaborating with Georgetown University to work toward testing SM-88 as a treatment for patients with hormonal positive and human epidermal growth factor receptor 2 negative (HR+/HER2-) advanced breast cancer who have received two prior hormonal therapies and failed or progressed after receiving a CDK4/6 inhibitor agent. The HR+/HER2- subtype represents 73% of breast cancer diagnoses in the United States. Enrollment is ongoing in the OASIS study, which is being conducted by Georgetown University through MedStar Health, its academic clinical partner, at five sites.

The trial is focused on tumor objective response rates, with the goal of finding an effective, well-tolerated, oral treatment for patients before they advance to chemotherapy treatment. Abstract Highlights: The initial studies were focused on assessing the effects of SM-88 (D/L-alpha-metyrosine; racemetyrosine) as a potential anti-cancer agent for ER+ tumor models that were either resistant or sensitive to antiestrogens agents and CDK4/6 inhibitors. The results that SM-88 alone showed antiproliferative effects in each of the sensitive and resistant cells lines, and that the combination of SM-88 and MPS had an additive effect in these models.

Ongoing work is focused on further defining the biochemical pathways in drug sensitive and resistant cells that will further support the current clinical use of SM-88 in advanced ER+ /HER2- breast cancer (ClinicalTrials.gov Identifier: NCT04720664).