Vertex Pharmaceuticals Incorporated announced three abstracts, including two oral presentations and one poster, detailing data on type 1 diabetes (T1D) and its Phase 1/2 trial of VX-880, a stem cell-derived, fully differentiated pancreatic islet cell replacement therapy, have been accepted for presentation during the American Diabetes Association 82nd Annual Scientific Sessions Conference held June 3-7, 2022 in New Orleans, Louisiana. Abstract and publication #259-OR entitled “Stem Cell-Derived, Fully Differentiated Islet Cells for Type 1 Diabetes,” will be presented on Monday, June 6, 2022 at 9:00 a.m. CDT during the oral presentation session “Other Therapeutic Agents,” which runs from 8:00 to 10:00 a.m. CDT. The abstract posted today details results from the Phase 1/2 clinical trial, demonstrating VX-880 can restore insulin production and glucose control in T1D.

Data will be updated and additional information will be presented at the conference. Abstract and publication #92-OR entitled “Persistence of Impaired Awareness of Hypoglycemia, Severe Hypoglycemic Events and Suboptimal Glycemic Control Despite Advanced Diabetes Technologies,” to be presented Saturday, June 4, 2022 at 1:45 p.m. CDT during the oral presentation session “Glucose Monitoring and Sensing,” which runs from 1:45 to 3:45 p.m. CDT. The abstract posted today, describing an online survey of 2,044 adults with T1D in the T1D Exchange registry and online communities, shows that in patients with high rates of diabetes technology adoption, such as continuous glucose monitoring, insulin pumps and hybrid closed loop systems, impaired awareness of hypoglycemia (IAH) and severe hypoglycemic events (SHEs) persist, with a substantial proportion of patients not achieving target glycemic control, indicating the need for novel T1D treatments.

Abstract and poster #652-P entitled “Gaps Remain in Achieving Target T1D Glycemic Goals Despite Advanced Technologies,” will be available as part of the general poster session to be held Saturday, June 4, 2022 from 11:30 a.m. to 2:30 p.m. CDT. The abstract posted today highlights that, despite improvements in glycemic control with diabetes technologies, many patients with T1D are still unable to achieve clinical targets and experience severe hypoglycemia, emphasizing the need for novel T1D treatments.