- Development of C21 in IPF on track; final Phase 2a AIR data in first half of 2024 and Phase 2b ASPIRE initiation in first half of 2024
- AlmeeTM pivotal study COMPANION completion on-track; topline results expected to be announced this month
- Transition to late-stage development of C21 in IPF drives increased focus in pipeline; preclinical IMiD program to be discontinued
- Review ongoing for follow-on indications and molecules to complement development of C21 in IPF
The updates announced today include confirmation that development of the lead program, C21 for IPF is on track, with final Phase 2a AIR[1] data in the first half of next year. In addition, start-up activities for the global, double-blind, placebo-controlled, 52-week, Phase 2b ASPIRE study of C21 for IPF are progressing with initiation expected in the first half of 2024. Development of the Almee digital therapy advances as well, with topline results of the COMPANION[2] pivotal study for anxiety associated with pulmonary fibrosis expected to be reported in
In its early-stage pipeline, as a result of an on-going portfolio review process that aims to focus investments, Vicore will discontinue development of the preclinical IMiD program, inhaled thalidomide for IPF cough. The review is also expected to select the best possible follow-on indications and ATRAG molecules for further development in view of the unique characteristics of this upstream mechanism of action that drives tissue repair.
“With the strong clinical signal for C21 in IPF demonstrated in its
“We are extremely committed to successful development of C21 for IPF,” said
“Activation of the angiotensin II type 2 receptor is a potent protective mechanism with strong potential beyond IPF,” said
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About
Vicore is an innovative clinical-stage pharmaceutical company unlocking the potential of a new class of drugs with disease-modifying potential. The company is establishing a portfolio in respiratory diseases, including idiopathic pulmonary fibrosis (IPF). C21 is a first-in-class orally available small molecule angiotensin II type 2 receptor agonist (ATRAG) currently in phase 2a development for IPF. Almee™ (an investigational medical device in clinical development) is a digital therapeutic based on cognitive behavioral therapy created to address the psychological impact of living with pulmonary fibrosis. Using its unique expertise in ATRAG chemistry and biology, Vicore is further fueling its pipeline with several new therapies across additional potential indications. The company’s shares (VICO) are listed on Nasdaq Stockholm’s main market. For more information, see www.vicorepharma.com.
[1] NCT04533022
[2] NCT05330312
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