On March 25, 2021, the Board of Directors of VolitionRx Limited received written notice from Dr. Salvatore Thomas Butera of his resignation from the Board and from the company's Audit Committee, Compensation Committee and Nominations and Governance Committee with immediate effect. Dr. Butera resigned from the Board to assume the role of Chief Executive Officer of Volition Veterinary Diagnostics Development, LLC, which role he will assume effective as of May 1, 2021, and was not due to any disagreement with the company on any matter relating to the company's operations, policies, practices or otherwise.