This patent is based on retrospective clinical data from XORTX scientific partners suggesting that an important therapeutic opportunity lies with addressing aberrant purine metabolism combined with hyperuricemia in patients most at risk to severe COVID-19 outcome. Since the advent of COVID-19 and during 2020, accumulating evidence suggests that individuals most at risk for more severe health consequences fall within a group that includes individuals with obesity, hypertension, metabolic syndrome, insulin resistance, pre-diabetes, diabetes or chronic kidney disease. These individuals have a higher incidence of hyperuricemia and endothelial dysfunction. Low grade systemic inflammation associated with these disease states and pre-existing vascular injury may suppress an individual’s ability to respond with a sufficiently robust response to fight infection and leaves the individual more prone to excessive pro-inflammatory and pro-coagulative state. This new patent filing proposes compositions of xanthine oxidase inhibitors, uric acid lowering agents and/or anti-viral agents alone or in combination, and methods for enhancing anti-viral therapies for the treatment of individuals most at risk.
Recent peer reviewed publications suggest that individuals with hyperuricemia appear to have an increased susceptibility to develop more severe sepsis associated with COVID-19 infection. Recent studies of Coronavirus infections show that SARS and MERS and specifically COVID-19 can be frequently accompanied by pneumonia, acute kidney injury, proteinuria and hematuria1,2. Viral load during infection has been reported to be associated with more severe symptoms.3 Acute kidney injury (“AKI”) has been identified as an independent risk factor for patients’ in-hospital mortality due to COVID-19 as well as other Coronavirus infections2. Associated with modest to severe COVID-19 infection is an increased risk of a hyper-inflammatory state, increased pro-coagulative state and bacterial infection - each can contribute to acute organ injury, and death. A higher incidence of bacterial or fungal infection is also associated with high mortality.4 Recent study results suggest that uric acid lowering can inhibit SARS-CoV-2 replication a finding that supports the clinical use of uric acid lowering agents to control SARS-CoV-2 infection in humans.5
The Company is not making any express or implied claims that it has the ability to eliminate, cure or contain the COVID-19 coronavirus at this time.
About
For further information, please contact:
adavidoff@xortx.com or +1 403 455 7727 | nick@alpineequityadv.com or +1 617 901 0785 |
The
References:
- Saraladevi Naicker,
Chih-Wei Yang ,Shang-Jyh Hwang ,Bi-Cheng Liu ,Jiang-Hua Chen , Vivekan and Jha, The Novel Coronavirus 2019 Epidemics and Kidneys,Kidney International March 2, 2020 . https://www.kidney-international.org/article/S0085-2538(20)30251-9/pdf. - Cheng, Y, Luo R., Wang K., Zhang M., Wang Z., Dong L., Li J, Yao Y., Ge S., Xu g., Kidney Impairment is associated with in-hospital deal of COVID-19 patients, medRxiv,
March 04, 2020 https://www.medrxiv.org/content/10.1101/2020.02.18.20023242v1. - Stankiwicz HC et al Trajectory of Viral RNA Load Among Persons with SARS-CoV-G614 Infection in Association with COVID-19 Symptom Onset and Severity JAMA
Jan 2022 - Zhou P et al Bacterial and fungal infections in COVID-19 patient_Infection Control & Hospital Epidemiology 1 2020
- Murray J et al Probenecid inhibits SARS-CoV-2 replication in vivo and in vitro Nature (11) 18085 2021
Forward Looking Statements
This press release may contain express or implied forward-looking statements pursuant to Canadian and
Source:
2022 GlobeNewswire, Inc., source