The project is based on mRNA coding for the Covid spike protein that could be used in an inhalable mRNA vaccine. It will include immunological tests to ensure the same responses are achieved in an inhaled vaccine as with an injection. The next stage of in-vivo testing in the project is expected to begin in April /
All results in first stages of project are positive
The positive findings relate to the particle morphology, cell borders and Mass Median Aerodynamic Diameter (MMAD). These are important metrics that describe the dry particle’s ability to ‘fly’ as an aerosol. The results demonstrate that LaminarPace has successfully been able to produce inhalable particles with the correct MMAD and morphology.
To achieve inhalable mRNA treatments
Inhalable solid dosage forms of mRNA vaccines are of great interest to the biopharmaceutic industry. They promise increased storage stability compared to liquid formulations, simplified and preferred patient administration avoiding injections and an ability to stimulate the mucosal immune system. LaminarPace was originally developed for inhalation purposes. Inhalable mRNA/LNP therapies do not exist on the market today, as the elevated temperatures of conventional drying methods are not applicable for the highly delicate mRNA/LNP materials. Ziccum’s technology LaminarPace is applied at room temperature with minimal stress factors, enabling a very gentle treatment compared to other methods.
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