On October 11, 2023, Ms. Lota Zoth, a member of the Board of Directors of Zymeworks Inc. notified the Company of her decision not to stand for re-election to the Board at the Company?s next annual meeting of stockholders to be held on or about December 7, 2023 (the ?2023 Annual Meeting?). Ms. Zoth will continue to serve as a member of the Board, lead independent director, chair of the audit committee and member of the compensation committee until the expiration of her term at the 2023 Annual Meeting. Ms. Zoth?s decision not to stand for re-election was not the result of any disagreement with the Company on any matter relating to the Company?s operations, policies or practices.