ZyVersa Therapeutics, Inc. announced a publication in the peer-reviewed journal, Diabetes, demonstrating the role of ASC in myocardial fibrosis induced by obesity. ASC is an inflammasome adaptor protein that has a critical role in inflammasome activation. In the paper titled, "Obesity enables NLRP3 activation and induces myocardial fibrosis via hyperacetylation ofADHa," the authors performed MRIs on obese and lean people and evaluated their plasma.

They also studied an animal model of obesity, with and without induced myocardial injury. Data indicate that: Activated NLRP3 inflammasomes leading to increased levels of proinflammatory IL-1b and IL-18 contribute to obesity-related myocardial fibrosis in obese humans and mice. Inflammasome ASC localized in the heart's mitochondria participates in NLRP3 inflammasome formation and activation based on mouse data.