* Canada became the first industrialized nation to legalize recreational cannabis on Wednesday, but a lawful buzz will be hard to come by in its biggest cities like Toronto and Vancouver, which will have no stores open.

* Aurora Cannabis fell 11.6 percent, the most on the TSX. The company said its Aurora Sky production plant was granted a sales license by Canada's healthcare regulator.

* Aphria, down 10 percent, was the second biggest decliner on the main index.

* At 9:42 a.m. ET (13:42 GMT), the Toronto Stock Exchange's S&P/TSX composite index was down 71.38 points, or 0.46 percent, at 15,508.36.

* Also weighing on the main index was the energy sector, which fell 0.9 percent as U.S. crude prices were down 1.1 percent per barrel, while Brent crude lost 0.8 percent. [O/R]

* Six of the index's 11 major sectors were lower, with the healthcare sector's 6.82 pct drop being the steepest.

* On the TSX, 69 issues were higher, while 172 issues declined for a 2.49-to-1 ratio to the downside, with traded volume touching 26.04 million shares.

* The largest percentage gainers on the TSX were First Majestic Silver, which rose 1.1 percent and Fortis Inc, which increased 0.9 percent.

* The most heavily traded shares by volume were Azarga Uranium , Aurora Cannabis and Aphria.

* The TSX posted no new 52-week highs and two new lows.

* Across all Canadian issues, there was only one new 52-week high and 7 new lows, with total volume of 57.15 million shares.

(Reporting by Amy Caren Daniel in Bengaluru; Editing by James Emmanuel)